Search / Trial NCT00001009

A Study of Dextran Sulfate in HIV-Infected Patients and in Patients With AIDS or AIDS Related Complex (ARC)

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

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Trial Information

Current as of July 14, 2024

Completed

Keywords

T Lymphocytes Hiv Antigens Dextran Sulfate Dose Response Relationship, Drug Drug Evaluation Drug Therapy, Combination Acquired Immunodeficiency Syndrome Aids Related Complex

Description

Although zidovudine (AZT) has shown promise in prolonging life in patients with AIDS and severe ARC, it has significant blood toxicities. It would be beneficial to combine AZT with another antiviral agent that does not have the same toxicity. DS might be a suitable drug since it has shown antiviral activity against HIV in the laboratory, and in preliminary studies it has shown little toxicity. Also, the combination of DS with AZT has been shown to be more effective than either alone. The study will begin with 10 patients with AIDS, 10 with ARC, and 10 with asymptomatic HIV infection taking...

Gender

All

Eligibility criteria

  • Inclusion Criteria
  • Concurrent Medication:
  • Allowed:
  • Aerosolized pentamidine for prophylaxis of Pneumocystis carinii pneumonia (PCP).
  • Acetaminophen.
  • Ketoconazole.
  • Consistently positive serum HIV p24 antigen = or > 70 picograms/ml, defined by the Abbott HIV antigen test, on two occasions, each within 1 month prior to entry, separated by at least 72 hours, the last of which must be within 2 weeks of starting therapy. Positive antibody to HIV with a federally licensed ELISA test kit.
  • Exclusion Criteria
  • Patients with any negative HIV p24 antigen test within 1 month of entry are excluded. Hemophiliacs are excluded.
  • Prior Medication:
  • Excluded within 4 weeks of study entry:
  • Biologic response modifiers.
  • Zidovudine (AZT) or other antiretroviral agents.
  • Other investigational drugs.
  • Excluded within 12 weeks of study entry:
  • Ribavirin.
  • Excluded:
  • Ongoing therapy and/or prophylaxis for an AIDS-defining opportunistic infection.
  • Anticoagulant drugs.
  • Systemic corticosteroids.
  • Aspirin.
  • Dextran sulfate.
  • Sedatives.
  • Barbiturates.
  • Prior Treatment:
  • Excluded within 2 weeks of study entry:
  • Transfusion.
  • Severe diarrhea:
  • = or > 5 loose or watery stools per day. Significant malabsorption:
  • > 10 percent weight loss within past 3 months with serum carotene < 75 IU/ml or vitamin A < 75 IU/ml. Transfusion dependent:
  • Requiring 2 units of blood > once a month. Active opportunistic infection. Symptomatic visceral Kaposi's sarcoma (KS), progression of KS within 1 month of entry, or concurrent neoplasms other than KS. Basal cell carcinoma of the skin or in situ carcinoma of the cervix. Hemorrhagic diseases such as hemophilia A or B or von Willebrand disease.
  • Active drug or alcohol abuse sufficient in the investigator's opinion to prevent adequate compliance with study therapy.

Attachments

readout_NCT00001009_2024-07-14.pdf

4.5 MB

NCT00001009_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Los Angeles, California, United States

New York, New York, United States

Worcester, Massachusetts, United States

Los Angeles, California, United States

San Francisco, California, United States

Minneapolis, Minnesota, United States

New York, New York, United States

Washington, District Of Columbia, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
4 stars
6
3 stars
2
2 stars
0
1 stars
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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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