A Study of Zidovudine Plus Acyclovir in HIV-Infected Patients
Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001
Trial Information
Current as of January 15, 2025
Completed
Keywords
ClinConnect Summary
Other studies have shown that AZT offers potential benefits to specific AIDS patients when given over long time periods, and experiments in vitro (in the test tube) suggest that ACV may stimulate the action of AZT against HIV. It is necessary to obtain information on how these drugs perform in HIV-infected humans.
The first 12 patients will take AZT capsules every 4 hours, and 6 of the patients will also take ACV 6 times a day. Later groups of patients will receive higher doses of AZT if the earlier doses are tolerated without significant adverse effect. It was initially planned to stop tr...
Gender
ALL
Eligibility criteria
- • Exclusion Criteria
- • Active drug or alcohol abuse.
- Concurrent Medication:
- Excluded:
- • Any chronic systemic medications.
- • Aspirin.
- • Cimetidine.
- • Flurazepam.
- • Indomethacin.
- • Ranitidine.
- • Probenecid.
- * Excluded during first 2 weeks of study:
- • Any chronic ( \> 3 days) medication.
- • Acetaminophen and other drugs that are metabolized by hepatic glucuronidation.
- Prior Medication:
- Excluded:
- • Zidovudine (AZT) at any time.
- * Excluded within 14 days of study entry:
- • Other experimental therapy.
- • Drugs which cause neutropenia or significant nephrotoxicity.
- • Rifampin or rifampin derivatives.
- • Systemic anti-infectives.
- * Excluded within 30 days of study entry:
- • Immunomodulating agents.
- * Excluded within 3 months of study entry:
- • Any antiretroviral agent.
- Patients may not have any of the following:
- • A gastrointestinal disturbance which may impair oral absorption.
- • Chronic persistent candidiasis.
- • An opportunistic infection or malignancy fulfilling the definition of AIDS-associated disease.
- • Patients with symptoms suggestive of an opportunistic infection should be evaluated within 30 days of starting drug.
- Patients may not have any of the following:
- • A gastrointestinal disturbance which may impair oral absorption.
- • Chronic persistent candidiasis.
- • An opportunistic infection or malignancy fulfilling the definition of AIDS-associated disease.
- • Patients with symptoms suggestive of an opportunistic infection should be evaluated within 30 days of starting drug.
- • All patients will have positive antibody for HIV confirmed by any federally licensed ELISA test kit; if ELISA is negative, eligibility will be confirmed by a positive Western blot.
- • All patients will have evidence of HIV infection in the plasma as indicated by circulatory p24 antigen within 30 days prior to study entry.
- * The symptomatic HIV infection required for inclusion is defined as at least one of the following:
- • Temperature \> 38.0 degrees C persisting for more than 14 consecutive days or more than 15 days in a 30-day interval prior to study entry without definable cause.
- • Diarrhea, defined as = or \> 3 liquid stools per day, persisting for more than 1 month prior to entry into the study without definable cause.
- • Weight loss greater than 10 percent of body weight noted in a 120-day period prior to entry into the study.
- • Patients with persistent generalized lymphadenopathy (PGL), defined as lymph node enlargement greater than 1 cm in diameter at two or more noncontiguous extrainguinal sites, who in addition to this adenopathy have constitutional symptoms such as intermittent fever (\> 38 degrees C for less than 15 days/month), sweats, malaise, and/or fatigue will also be eligible. This patient population has to have T4 cell counts = or \< 500. Potential enrollees with PGL must have two screening lymphocyte subset determinations, at least 72 hours apart, within 3 months of entry that fall in the appropriate T4 range (200 - 500 cells/mm3). If an otherwise eligible subject has one screening T4 count in the appropriate range and one that is outside this range, a third screening count will determine eligibility.
Trial Officials
Corey L
Study Chair
About National Institute Of Allergy And Infectious Diseases (Niaid)
The National Institute of Allergy and Infectious Diseases (NIAID) is a key component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of infectious and immune-mediated diseases. Through rigorous clinical trials, NIAID aims to foster innovative research that enhances public health and addresses global health challenges, including emerging infectious diseases and allergies. The institute collaborates with various partners, including academic institutions, industry, and international organizations, to translate scientific discoveries into effective therapies and vaccines. NIAID's commitment to high-quality clinical research is integral to improving health outcomes and informing policy decisions in the realm of infectious diseases and immunology.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Los Angeles, California, United States
Seattle, Washington, United States
San Diego, California, United States
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
Similar Trials