Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

Your child will be assigned randomly (like tossing a coin) to receive either cidofovir or placebo (an inactive substance). Neither you nor your doctor will know which your child is receiving. Your child will undergo a total of 6 bronchoscopic procedures, which involves placing a tube down your child's throat so that the warts can be seen and treated. The warts will be removed by laser or other procedures and the study drug injected. Study drug will be injected at the sites of all newly removed warts and warts which were removed during earlier study visits. This procedure will be performed e...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Your child may be eligible for this study if he/she:
• • Has active laryngeal papillomatosis (warts in the throat) that requires 8 or more surgeries per year.
• • Developed this infection before the age of 16.
• • Is between the ages of 2 and 17 years with consent of parent or guardian.
• Exclusion Criteria:
• Your child will not be eligible for this study if he/she:
• • Has a history of a prior malignancy (cancer), kidney disease, or immune system deficiency.
• • Is HIV-positive.
• • Is allergic to probenecid.
• • Has received radiation therapy to the throat area or has received certain medications.
• • Is pregnant or breast-feeding.