Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)
Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001
Current as of December 10, 2023
Your child will be assigned randomly (like tossing a coin) to receive either cidofovir or placebo (an inactive substance). Neither you nor your doctor will know which your child is receiving. Your child will undergo a total of 6 bronchoscopic procedures, which involves placing a tube down your child's throat so that the warts can be seen and treated. The warts will be removed by laser or other procedures and the study drug injected. Study drug will be injected at the sites of all newly removed warts and warts which were removed during earlier study visits. This procedure will be performed e...
- Inclusion Criteria:
- Your child may be eligible for this study if he/she:
- Has active laryngeal papillomatosis (warts in the throat) that requires 8 or more surgeries per year.
- Developed this infection before the age of 16.
- Is between the ages of 2 and 17 years with consent of parent or guardian.
- Exclusion Criteria:
- Your child will not be eligible for this study if he/she:
- Has a history of a prior malignancy (cancer), kidney disease, or immune system deficiency.
- Is HIV-positive.
- Is allergic to probenecid.
- Has received radiation therapy to the throat area or has received certain medications.
- Is pregnant or breast-feeding.
The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Birmingham, Alabama, United States
All reviews come from applied patients