Nctid:
NCT00001167
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-10-21"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D000009369", "term"=>"Neoplasms"}, {"id"=>"D000010610", "term"=>"Pharyngeal Neoplasms"}, {"id"=>"D000010039", "term"=>"Otorhinolaryngologic Neoplasms"}, {"id"=>"D000017285", "term"=>"Polymyositis"}, {"id"=>"D000010038", "term"=>"Otorhinolaryngologic Diseases"}, {"id"=>"D000013064", "term"=>"Speech Disorders"}], "ancestors"=>[{"id"=>"D000009220", "term"=>"Myositis"}, {"id"=>"D000009135", "term"=>"Muscular Diseases"}, {"id"=>"D000009140", "term"=>"Musculoskeletal Diseases"}, {"id"=>"D000009468", "term"=>"Neuromuscular Diseases"}, {"id"=>"D000009422", "term"=>"Nervous System Diseases"}, {"id"=>"D000007806", "term"=>"Language Disorders"}, {"id"=>"D000003147", "term"=>"Communication Disorders"}, {"id"=>"D000019954", "term"=>"Neurobehavioral Manifestations"}, {"id"=>"D000009461", "term"=>"Neurologic Manifestations"}, {"id"=>"D000006258", "term"=>"Head and Neck Neoplasms"}, {"id"=>"D000009371", "term"=>"Neoplasms by Site"}, {"id"=>"D000010608", "term"=>"Pharyngeal Diseases"}, {"id"=>"D000009057", "term"=>"Stomatognathic Diseases"}], "browseLeaves"=>[{"id"=>"M13157", "name"=>"Paralysis", "relevance"=>"LOW"}, {"id"=>"M19579", "name"=>"Polymyositis", "asFound"=>"Polymyositis", "relevance"=>"HIGH"}, {"id"=>"M6882", "name"=>"Deglutition Disorders", "relevance"=>"LOW"}, {"id"=>"M21089", "name"=>"Facies", "relevance"=>"LOW"}, {"id"=>"M10835", "name"=>"Laryngeal Diseases", "relevance"=>"LOW"}, {"id"=>"M15864", "name"=>"Speech Disorders", "asFound"=>"Speech Disorders", "relevance"=>"HIGH"}, {"id"=>"M12962", "name"=>"Otorhinolaryngologic Neoplasms", "asFound"=>"Otorhinolaryngologic Neoplasms", "relevance"=>"HIGH"}, {"id"=>"M22138", "name"=>"Bell Palsy", "relevance"=>"LOW"}, {"id"=>"M8301", "name"=>"Facial Paralysis", "relevance"=>"LOW"}, {"id"=>"M7575", "name"=>"Dysarthria", "relevance"=>"LOW"}, {"id"=>"M17724", "name"=>"Xerostomia", "relevance"=>"LOW"}, {"id"=>"M12961", "name"=>"Otorhinolaryngologic Diseases", "asFound"=>"Otorhinolaryngologic Diseases", "relevance"=>"HIGH"}, {"id"=>"M13517", "name"=>"Pharyngeal Neoplasms", "asFound"=>"Pharyngeal Neoplasms", "relevance"=>"HIGH"}, {"id"=>"M12172", "name"=>"Myositis", "relevance"=>"LOW"}, {"id"=>"M12092", "name"=>"Muscular Diseases", "relevance"=>"LOW"}, {"id"=>"M12097", "name"=>"Musculoskeletal Diseases", "relevance"=>"LOW"}, {"id"=>"M12411", "name"=>"Neuromuscular Diseases", "relevance"=>"LOW"}, {"id"=>"M10823", "name"=>"Language Disorders", "relevance"=>"LOW"}, {"id"=>"M6374", "name"=>"Communication Disorders", "relevance"=>"LOW"}, {"id"=>"M21826", "name"=>"Neurobehavioral Manifestations", "relevance"=>"LOW"}, {"id"=>"M12404", "name"=>"Neurologic Manifestations", "relevance"=>"LOW"}, {"id"=>"M9348", "name"=>"Head and Neck Neoplasms", "relevance"=>"LOW"}, {"id"=>"M13515", "name"=>"Pharyngeal Diseases", "relevance"=>"LOW"}, {"id"=>"M12017", "name"=>"Stomatognathic Diseases", "relevance"=>"LOW"}, {"id"=>"T4623", "name"=>"Polymyositis", "asFound"=>"Polymyositis", "relevance"=>"HIGH"}, {"id"=>"T707", "name"=>"Bell's Palsy", "relevance"=>"LOW"}, {"id"=>"T3001", "name"=>"Idiopathic Inflammatory Myopathy", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Nervous System Diseases", "abbrev"=>"BC10"}, {"name"=>"Symptoms and General Pathology", "abbrev"=>"BC23"}, {"name"=>"All Conditions", "abbrev"=>"All"}, {"name"=>"Musculoskeletal Diseases", "abbrev"=>"BC05"}, {"name"=>"Digestive System Diseases", "abbrev"=>"BC06"}, {"name"=>"Ear, Nose, and Throat Diseases", "abbrev"=>"BC09"}, {"name"=>"Respiratory Tract (Lung and Bronchial) Diseases", "abbrev"=>"BC08"}, {"name"=>"Neoplasms", "abbrev"=>"BC04"}, {"name"=>"Infections", "abbrev"=>"BC01"}, {"name"=>"Mouth and Tooth Diseases", "abbrev"=>"BC07"}, {"name"=>"Behaviors and Mental Disorders", "abbrev"=>"BXM"}, {"name"=>"Rare Diseases", "abbrev"=>"Rare"}]}}, "protocolSection"=>{"designModule"=>{"studyType"=>"OBSERVATIONAL", "enrollmentInfo"=>{"count"=>570}}, "statusModule"=>{"overallStatus"=>"COMPLETED", "startDateStruct"=>{"date"=>"1979-08"}, "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2004-11", "completionDateStruct"=>{"date"=>"2004-11"}, "lastUpdateSubmitDate"=>"2008-03-03", "studyFirstSubmitDate"=>"1999-11-03", "studyFirstSubmitQcDate"=>"1999-11-03", "lastUpdatePostDateStruct"=>{"date"=>"2008-03-04", "type"=>"ESTIMATED"}, "studyFirstPostDateStruct"=>{"date"=>"1999-11-04", "type"=>"ESTIMATED"}}, "conditionsModule"=>{"keywords"=>["Dysphagia", "Dysarthria", "Tongue Motion", "Xerostomia", "Swallowing", "Speech", "Polymyositis", "Speech Disorders", "Oral-Facial Paralysis", "Ultrasound"], "conditions"=>["Otorhinolaryngologic Disease", "Otorhinolaryngologic Neoplasm", "Pharyngeal Neoplasm", "Polymyositis", "Speech Disorder"]}, "referencesModule"=>{"references"=>[{"pmid"=>"2011159", "type"=>"BACKGROUND", "citation"=>"Sonies BC, Dalakas MC. Dysphagia in patients with the post-polio syndrome. N Engl J Med. 1991 Apr 25;324(17):1162-7. doi: 10.1056/NEJM199104253241703."}, {"pmid"=>"2381441", "type"=>"BACKGROUND", "citation"=>"Sonies BC, Ekman EF, Andersson HC, Adamson MD, Kaler SG, Markello TC, Gahl WA. Swallowing dysfunction in nephropathic cystinosis. N Engl J Med. 1990 Aug 30;323(9):565-70. doi: 10.1056/NEJM199008303230903."}, {"pmid"=>"6398320", "type"=>"BACKGROUND", "citation"=>"Shawker TH, Sonies B, Hall TE, Baum BF. Ultrasound analysis of tongue, hyoid, and larynx activity during swallowing. Invest Radiol. 1984 Mar-Apr;19(2):82-6. doi: 10.1097/00004424-198403000-00003."}]}, "descriptionModule"=>{"briefSummary"=>"This study will assess the use of ultrasound-a test that uses sound waves to produce images-as a diagnostic tool for evaluating speech and swallowing.\n\nThe following categories of individuals may be eligible for this study: 1) healthy volunteers between 20 and 85 years old with normal speech and hearing, 2) patients 6 to 85 years old with developmental neurological deficits in speech or swallowing, and 3) patients with tumors of the oral cavity, pharynx or larynx being treated at the Greater Baltimore Medical Center.\n\nParticipants will undergo a 30-minute speech and oral motion evaluation, in which they imitate sounds, words and oral movements while a speech pathologist evaluates their lip, tongue and palate movements. They may also be asked to drink a small amount of water for examination of swallowing function.\n\nFor the ultrasound examination, a 3/4-inch transducer (device for transmitting and receiving sound waves) is placed under the participant's chin. While the transducer is in place, the subject 1) repeats sounds and a series of syllables in several sequences, 2) swallows three times with and without a small amount of water, and 3) swallows 3 teaspoons of non-fat pudding. The ultrasound images are recorded on tape for later analysis.", "detailedDescription"=>"Studies conducted using ultrasound imaging at the NIH, Departments of Rehabilitation Medicine and Diagnostic Radiology, have demonstrated that ultrasound imaging can be used reliably to study speech and swallowing impairments in a variety of conditions and diseases. Since ultrasound is non-invasive with no reported bioeffects, it can be used repeatedly to follow the progression of a disease. Ultrasound imaging of the oral cavity during speech and swallowing allows easy visualization of the tongue/hyoid bone motion and transport of the bolus during swallowing and tongue surface configuration during speech. Images can be obtained in several planes for viewing muscular coordination and timing and specific measures can be obtained from digitized video images. Thus it has widespread clinical research implications for patients with disorders affecting the oral peripheral muscles, salivary gland flow and the central nervous system control of speech and swallowing. While ultrasound technology has been used extensively in Europe to evaluate tumors of the head and neck, its use in this country has been marginal. We plan to compare ultrasound evaluation of tumor staging, tumor volume, and tumor recurrence in patients with tumors of the larynx, oral cavity and hypopharynx. Currently, this is accomplished by CT or MRI scanning procedures. We plan to compare CT/MRI results with ultrasound to determine if this non-invasive technique can be utilized reliably for diagnosis and tracking of oropharyngeal tumors."}, "eligibilityModule"=>{"sex"=>"ALL", "stdAges"=>["CHILD", "ADULT", "OLDER_ADULT"], "healthyVolunteers"=>true, "eligibilityCriteria"=>"INCLUSION CRITERIA:\n\nNormal volunteers:\n\nNormal volunteers ages 21 to 85 may be asked to participate in a study of speech and swallowing utilizing a traditional clinical examination of oral-motor performance. If the subjects are without deficits in dental occlusion, speech articulation, tongue and lip strength, tongue and lip mobility, palatal function and oral sensation they will be asked to participate in an ultrasonic evaluation of tongue/hyoid interaction during swallowing and speech.\n\nChildren will be included if they are referred with a medical condition that affects the oral pharyngeal phase of swallowing, voice production or laryngeal function and the investigator needs to evaluate functional performance and safety for oral feeding.\n\nNeurological Group:\n\nSubjects aged 6 to 85 with diagnosed developmental, neuromotor, systemic, genetic, neurologic, structural and post surgical dysfunction who have deficits in speech (dysarthria) and/or swallow (dysphagia) may be asked to participate in this study of ultrasonic imaging. Aging patients with and without dementia may also be studied. Patients with Post Polio Syndrome, Polymyositis, Dermatomyositis, Toricollis, Cerebellar Degeneration, Parkinson's disease, Progressive Supranuclear Palsy, ALS, Cystinosis, are among the conditions of interest. Subjects with complaints of oral dryness, and patients who have undergone mandibular and oral surgery may also be studied during swallowing.\n\nOropharyngeal/Laryngeal Tumors:\n\nPatients will be seen who are enrolled in NCI and NIDCD protocols for head and neck tumors.\n\nEXCLUSION CRITERIA\n\nNormal Subjects:\n\nHearing impairment reported (above 40 db, bilaterally)\n\nDentures\n\nOral Prosthesis\n\nPalatal surgery or other restorative dental surgery\n\nRadial neck dissection, glossectomy\n\nTumor or masses in neck or tongue\n\nCerebral vascular attack\n\nStuttering\n\nNon-English speaker\n\nChildhood articulation impairment"}, "identificationModule"=>{"nctId"=>"NCT00001167", "briefTitle"=>"Ultrasound Evaluation of Tongue Movements in Speech and Swallowing", "organization"=>{"class"=>"NIH", "fullName"=>"National Institutes of Health Clinical Center (CC)"}, "officialTitle"=>"Exploration of the Diagnostic Capabilities of Ultrasound of the Oropharynx and Larynx", "orgStudyIdInfo"=>{"id"=>"790101"}, "secondaryIdInfos"=>[{"id"=>"79-CC-0101"}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"20892", "city"=>"Bethesda", "state"=>"Maryland", "country"=>"United States", "facility"=>"Warren G. Magnuson Clinical Center (CC)", "geoPoint"=>{"lat"=>38.98067, "lon"=>-77.10026}}]}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"National Institutes of Health Clinical Center (CC)", "class"=>"NIH"}}}}
