Evaluation of the Genetics of Bipolar Disorder

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Nov 3, 1999

Keywords

ClinConnect Summary

This clinical trial, called the "Evaluation of the Genetics of Bipolar Disorder," aims to find out which genes might influence a person's risk of developing bipolar disorder and related conditions. Researchers are particularly interested in understanding the genetic links to this mental health issue, which can affect mood and behavior.

If you are 18 years or older and have bipolar disorder, or if you are a close relative of someone who does, you may be eligible to participate. It's important that you can provide a blood or saliva sample safely and that you do not have active substance abuse issues. Participants will undergo a simple procedure to provide these samples, and in return, they will help researchers uncover important genetic information that could improve understanding and treatment of bipolar disorder. This study is currently looking for volunteers from all genders, and it’s a great opportunity to contribute to mental health research!

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• In order to be eligible to participate in this study, an individual must meet all of the following criteria:
• • 1. Stated willingness to comply with all study procedures and availability for the duration of the study.
• • 2. Male or female, aged 18 years and over. Children are excluded for the following reasons: age at onset of BD is usually later than age 18, the diagnostic and assessment instruments we use are not validated in children.
• • 3. In good general health as evidenced by medical history or diagnosed with or exhibiting symptoms of bipolar disorder or related conditions not attributable to substance abuse, or neurological disease; OR a 1st or 2nd degree relative of an enrolled participant. Related conditions are defined as those found more often among relatives of people with bipolar disorder or which have been shown to be genetically correlated with bipolar disorder through molecular genetic studies. These include major depression, schizophrenia, panic disorder, and attention deficit hyperactivity disorder.
• • 4. Ability to safely provide a blood or saliva sample.
• • 5. Ability of subject to understand and willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• An individual who meets any of the following criteria will be excluded from participation in this study:
• • 1. Active alcohol or substance abuse.
• • 2. Subjects who suffer cognitive impairment and are unable to provide an accurate psychiatric history are excluded since much of the diagnostic information relies on selfreport and recall of past events.