Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Nov 3, 1999

Keywords

ClinConnect Summary

Familial hypercholesterolemia is an autosomal co-dominant disorder resulting in abnormal LDL receptor function, profoundly elevated concentrations of low density lipoproteins, accelerated atherosclerosis and death by early adulthood. This disease is heterogeneous in both the degree of LDL receptor dysfunction as well as the age of death. Liver transplantation has been demonstrated to virtually normalize plasma lipoprotein concentrations in homozygous FH and the recent cloning of a functional LDL receptor gene holds promise in the definitive treatment of this condition. We propose performing...

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Eligibility criteria

• * INCLUSION CRITERIA:
• • Fasting cholesterol greater than 500 mg/dl, low density lipoprotein cholesterol greater than 400 mg/dl, and triglycerides less than mg/dl.
• • Family history of hypercholesterolemia and/or cardiovascular disease before the age of 60 years.
• • Tendinous and tuberous xanthomas.
• • Arcus corneae before the age of 30.

Trial Officials