Search / Trial NCT00001230

Host Response to Infection and Treatment in Filarial Diseases

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Trial Information

Current as of December 26, 2024

Recruiting

Keywords

Wuchereria Bancrofti Loa Loa Brugia Malayi Onchocerca Volvulus Filarial Infection Natural History

ClinConnect Summary

This clinical trial is focused on studying filarial infections, which are caused by parasitic worms transmitted through mosquito bites. The researchers aim to understand how the body's immune system responds to these infections and how patients can be effectively treated. People aged between 3 and 100 years who have been diagnosed with or are suspected of having a filarial infection, such as Wuchereria bancrofti or Onchocerca volvulus, may be eligible to participate.

Participants in the study will undergo routine tests to identify the specific type of infection, which may include skin or lung examinations. While the study doesn’t involve experimental treatments, it will include some additional procedures, like extra blood tests and skin tests to check for allergies. Treatment will be provided using standard medications once the diagnosis is confirmed. Participants can expect more frequent check-ups and follow-ups than usual as part of the study. If you or someone you know might be eligible, this could be an important opportunity to contribute to our understanding of these infections.

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Age 3-100 years.
  • Access to a primary medical care provider outside of the NIH.
  • Ability to give informed consent.
  • Clinical evidence suggestive of a filarial infection
  • EXCLUSION CRITERIA:
  • Although pregnant or nursing women can be enrolled, they will be excluded from receiving treatment while pregnant or breastfeeding
  • Less than 3 year of age; greater than 100 years of age
  • Any condition that the investigator feels put the subject at unacceptable risk for participation in the study

Trial Officials

Thomas B Nutman, M.D.

Principal Investigator

National Institute of Allergy and Infectious Diseases (NIAID)

About National Institute Of Allergy And Infectious Diseases (Niaid)

The National Institute of Allergy and Infectious Diseases (NIAID) is a key component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of infectious and immune-mediated diseases. Through rigorous clinical trials, NIAID aims to foster innovative research that enhances public health and addresses global health challenges, including emerging infectious diseases and allergies. The institute collaborates with various partners, including academic institutions, industry, and international organizations, to translate scientific discoveries into effective therapies and vaccines. NIAID's commitment to high-quality clinical research is integral to improving health outcomes and informing policy decisions in the realm of infectious diseases and immunology.

Locations

Bethesda, Maryland, United States

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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