Search / Trial NCT00001278

Study of Eye Tissue for Sarcoidosis

Launched by NATIONAL EYE INSTITUTE (NEI) · Dec 9, 2002

Trial Information

Current as of December 26, 2024

Completed

Keywords

Conjunctival Biopsy Lacrimal Gland Biopsy Sarcoid Uveitis Sarcoidosis Conjunctiva Inflammatory Eye Disease

ClinConnect Summary

The purpose of this study is to develop a method of diagnosing sarcoidosis in patients with presumed sarcoid uveitis. We plan to test conjunctival and lacrimal gland biopsy specimens from three groups of patients: patients with known, biopsy proven sarcoidosis, patients with suspected sarcoidosis, and patients with uveitis of an etiology other than sarcoidosis. Specimens will be tested for presence of cytokines, cell surface markers, and specific T cell receptor gene elements with immunohistochemical techniques using monoclonal antibodies. It has been shown that the diagnostic value of conj...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Biopsy proven sarcoidosis with intraocular inflammatory eye disease.
  • Intraocular inflammatory eye disease with suspected sarcoidosis based on age, race and characteristic granulomatous intraocular inflammation.
  • Inflammatory eye disease of a known etiology other than sarcoidosis.
  • Age greater than 18 years.
  • Can not have known bleeding diathesis, ocular infection, known allergy to local anesthetic agent or current treatment with a monoamine oxidase inhibitor, or vision worse than 20/400 in either eye.

About National Eye Institute (Nei)

The National Eye Institute (NEI), part of the U.S. National Institutes of Health (NIH), is dedicated to conducting and supporting innovative research to understand, prevent, and treat eye diseases and vision disorders. As a leading sponsor of clinical trials, NEI aims to advance knowledge in ocular health through rigorous scientific inquiry and collaboration with researchers, healthcare professionals, and institutions. By fostering the development of new therapies and technologies, NEI plays a pivotal role in enhancing the quality of life for individuals affected by visual impairments and eye conditions.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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