Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how the immune system responds to infections like HIV and what factors might weaken this response. Researchers want to learn more about how HIV affects immune cells and the substances they produce, which can either help or hinder the body's ability to fight off infections. Both individuals living with HIV and those without it can participate in the study. To join, participants must be at least 18 years old, have good blood pressure and blood counts, and be willing to provide informed consent.

Participants will need to donate blood and possibly other fluids, with a maximum of about 1 pint of blood drawn over six weeks. They'll also undergo some routine medical evaluations, including blood tests. The collected samples will be used for various tests, including screening for liver infections and genetic testing to understand how the immune system works. This study aims to gather valuable information that could help improve treatments for HIV and similar conditions.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • 18 years of age or older.
• • Adequate venous access.
• • Have a blood pressure less than or equal to 180/100: pulse rate 50-100, unless a lower pulse rate is considered normal for the volunteer.
• • Have adequate blood counts (volunteers living with HIV: hemoglobin greater than or equal to 9.0 g/dL, platelets greater than or equal to 50,000; volunteers living without HIV: hemoglobin greater than or equal to 9.0 g/dL, platelets greater than or equal to 50,000
• • Be willing and able to provide written informed consent on screening, comply with study requirements and procedures, and comply with clinic policies
• • Willingness to allow blood samples to be used for future studies of HIV infection/pathogenesis, and undergo hepatitis screening
• EXCLUSION CRITERIA:
• • Pregnant and/or breastfeeding females.
• • Active substance abuse or history of prior substance abuse that may interfere with protocol compliance or compromise volunteer safety.

Trial Officials