Evaluation and Long-Term Follow-up of Patients With Inflammatory Disorders

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Keywords

ClinConnect Summary

This is an observational, long‑term study at the NIH Clinical Center in Bethesda, Maryland. It focuses on inflammatory conditions—the body’s immune response that can come with infections or other immune problems. The study isn’t testing a new drug. Instead, it keeps a group of patients for ongoing follow‑up and to help researchers learn more, support other NIAID studies, and train clinical staff. Participants will have thorough health assessments (history, physical exams, and routine labs), and may have imaging or other tests as needed. If any medicines are used, they will be FDA‑approved. Some participants may be asked to donate extra blood for research, within safe limits.

Who can join? Adults and children aged 2 years and older (both sexes) with inflammatory conditions related to infections or immune disorders may be eligible, as determined by the study doctors. An NIH investigator must supervise the person’s care, and willing participants (and, if appropriate, their immediate family members) may undergo evaluation to see if further study is needed. People must be willing to have samples stored for research and to participate in long‑term follow‑up. This study is enrolling by invitation and aims to enroll up to about 500 people; it’s not a treatment trial, and no guaranteed personal benefit is promised beyond the potential for closer medical monitoring and contribution to future research. Location is the NIH Clinical Center in Bethesda, MD, led by the NIAID.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITIERIA:
• • Males and females ages 2 years and older.
• • Inflammatory conditions associated with, but not limited, to acute and chronic infections or presumed infections, and congenital or acquired immunologic disorders, as determined by the principal or associated investigators.
• • A NIAID/LCIM investigator has an interest in the patient s illness and is willing to serve as attending physician to supervise the patient's medical care at the NIH.
• • If appropriate, immediate family members of patients with inflammatory conditions may be evaluated under this protocol to determine if they may also be affected by their relative s disease.
• • Willingness to participate in clinical protocols when appropriate.
• • Subjects must maintain a primary physician outside NIH for non-protocol related medical complaints and for emergency medical treatment required for these or other of their disorders.
• • Willingness to have samples stored and to provide tissue samples for studying immune dysregulation and for genetic analysis.
• • Ablility to provide informed consent or, for the patient cohort, has a designated legally authorized representative (LAR).
• • For females, not pregnant.