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Search / Trial NCT00001363

PET Scan to Map the Areas of the Brain Involved in Planning

Launched by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) · Dec 9, 2002

Trial Information

Current as of January 15, 2025

Completed

Keywords

Blood Flow Chess Play Frontal Lobe Neurobehavioral Deficits Neuropsychology Positron Emission Tomography Prefrontal Cortex

ClinConnect Summary

This protocol will attempt to determine the topographical distribution in the brain of the cognitive components of planning using the \[150\] water PET blood flow technique. We will administer perception, motor, simple decision, and planning tasks using the game of chess and the Tower of Hanoi Test as paradigms. Utilizing a "subtraction technique" we hope to identify those areas of cerebral cortex which are most activated by planning processes. It is predicted that the dorsolateral frontal areas will be most prominently activated. It is also predicted that the essential components of the pl...

Gender

ALL

Eligibility criteria

  • Normal Controls:
  • Males and female subjects from two age ranges: 18-30 and 50-65 years of age.
  • Individuals with a history of neurological or psychiatric disorder will not be included nor will individuals currently taking psychoactive medication.
  • Patients:
  • Patients with outstanding problems in planning.
  • Patients must have a diagnosed CNS disorder with lesion localization verified by MRI scanning available from the referring physician or completed at the NIH Clinical Center.
  • Patients with unilateral or bilateral lesions that meet the behavioral criteria for selection (planning disorder).
  • Patients will be medication free (or taking medication with no known central nervous system effects) and be able to understand instructions and task demands.

About National Institute Of Neurological Disorders And Stroke (Ninds)

The National Institute of Neurological Disorders and Stroke (NINDS) is a leading component of the National Institutes of Health (NIH), dedicated to advancing our understanding of the brain and nervous system through innovative research. NINDS sponsors and conducts clinical trials aimed at developing effective treatments and improving patient outcomes for a wide range of neurological disorders, including stroke, epilepsy, multiple sclerosis, and neurodegenerative diseases. By fostering collaboration among researchers, healthcare providers, and patient communities, NINDS plays a pivotal role in transforming scientific discoveries into clinical applications, ultimately enhancing the quality of life for individuals affected by neurological conditions.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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