Current as of December 10, 2023
Deterioration in left ventricular function, which is characteristic in patients with congestive heart failure, appears to be a multifactorial process. Beta-blockers appear to reverse the deterioration and frequently improve left ventricular function in patients with both ischemic and non-ischemic cardiomyopathies. The mechanism by which beta-blockers improve ejection fraction is not known. Although it is well established that regional flow, function and metabolism may improve after coronary revascularization whether beta-blocker therapy will have similar salutary results in patients with co...
- Left ventricular ejection fraction by radionuclide angiography of less than or equal to 40%.
- New York Heart Association class II, III or IV symptoms on standard heart failure medications which my include digoxin, diuretics and angiotensin converting enzyme inhibitors for at least one month prior to enrollment.
- Ischemic cardiomyopathy if enzymes document an MI or 70% or greater stenosis in one major vessel.
- Dilated cardiomyopathy-if no coronary disease.
- No pregnant or lactating women.
- No women of child-bearing age not on proven birth control.
- No severe hepatic or renal disease.
- No diabetes mellitus or fasting glucose greater than or equal to 120 mg/dl.
- No primary valvular heart disease.
- No PTCA or CABG within 3 months of enrollment.
- No history of myocardial infarction or unstable angina within past 2 months.
- No resting heart rate less than 60 bpm.
- No A-V block greater than 1 degree block without pacemaker.
- No severe ETOH abuse within 6 months of enrollment.
- No severe bronchospasm.
The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, Maryland, United States
All reviews come from applied patients