Search / Trial NCT00001406

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Trial Information

Current as of December 14, 2024

Recruiting

Keywords

Eosinophils Helminth Parasites Hypereosinophilia Allergy Asthma Natural History

ClinConnect Summary

This clinical trial is studying eosinophils, which are a type of white blood cell that can increase in number due to allergies, asthma, and certain infections. The researchers want to understand how and why these cells become active and what role they play in our immune system. Elevated eosinophil levels, known as eosinophilia, can sometimes lead to symptoms like swelling, itching, or even more serious issues, though many people may not experience any problems at all.

To participate in this study, individuals aged 1 to 100 who have high eosinophil counts or abnormal eosinophil accumulation in their skin or tissues may be eligible. Participants will go through a thorough medical exam and various tests, including blood tests and possibly additional evaluations based on their age and symptoms. It’s important to note that this study is not about providing new treatments; participants will receive standard medical care as needed. Some may also be asked to provide extra blood samples for research purposes, and procedures like bone marrow testing or genetic testing may be included. All information will be kept confidential.

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • To be eligible to participate in this study, an individual must meet all of the following criteria:
  • 1. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 2. Male or female, aged 1-100
  • 3. Ability of subject (or Legally Authorized Representative (LAR)) to understand and sign a written informed consent document
  • Eosinophilic Patients only:
  • 4. Documented peripheral blood count \>1500/mm3, tissue eosinophilia (abnormal accumulation of eosinophils in the skin or other body tissues) or suspected eosinophilic end organ involvement
  • 5. Primary (non-NIH) physician for routine medical care
  • Relatives only:
  • 6. Extended family member of an eosinophilic participant on this protocol
  • EXCLUSION CRITERIA:
  • An individual who meets any of the following criteria will be excluded from participation in this study:
  • 1. Any condition(s) or diagnosis, physical and/or psychological, that the investigator feels precludes the patient from participation in the study.
  • Relatives only:
  • 2. Females must not be pregnant

Trial Officials

Amy D Klion, M.D.

Principal Investigator

National Institute of Allergy and Infectious Diseases (NIAID)

About National Institute Of Allergy And Infectious Diseases (Niaid)

The National Institute of Allergy and Infectious Diseases (NIAID) is a key component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of infectious and immune-mediated diseases. Through rigorous clinical trials, NIAID aims to foster innovative research that enhances public health and addresses global health challenges, including emerging infectious diseases and allergies. The institute collaborates with various partners, including academic institutions, industry, and international organizations, to translate scientific discoveries into effective therapies and vaccines. NIAID's commitment to high-quality clinical research is integral to improving health outcomes and informing policy decisions in the realm of infectious diseases and immunology.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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