Search / Trial NCT00001408

Role of T-Cells in Asthma

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

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Trial Information

Current as of December 10, 2023

Completed

Keywords

Lymphocytes Asthma Cytokines Interleukin 5 Late Phase Response

Description

In the last 10 years it has become generally accepted that asthma is an inflammatory disease of the airways. T lymphocytes play a key role in regulating this inflammatory response, through the elaboration of cytokines such as IL-4, IL-5, and IFN-gamma. IL-5 is of particular interest because it is the major eosinophil survival factor in vivo. Eosinophils are felt to be the major effector cells in asthma, causing damage to various airway structures. The pulmonary late phase response, a worsening of airflow seen 4-8 hours after allergen inhalation, is associated with many of the inflammatory ...

Gender

All

Eligibility criteria

  • INCLUSION CRITERIA - BLOOD DRAW/ASTHMA:
  • Age 18-65.
  • Asthma of greater than one year duration.
  • Willingness to adhere to effective contraception in women of child bearing age.
  • Negative HIV test.
  • EXCLUSION CRITERIA - BLOOD DRAW/ASTHMA:
  • For blood draws of greater than 100 ml, a hemoglobin of less than 12.5 g/dl. For blood draws of 100 ml or less, performed less frequently than every 56 days, a hemoglobin of less than 10.0 g/dl.
  • Current pregnancy.
  • Medical history suggesting lung diseases other than asthma.
  • History of immunodeficiency or HIV infection.
  • INCLUSION CRITERIA - BLOOD DRAW/NORMAL CONTROL:
  • Age 18-65.
  • Willingness to adhere to effective contraception in women of child bearing age.
  • Negative HIV test.
  • EXCLUSION CRITERIA - BLOOD DRAW/NORMAL CONTROL:
  • For blood draws of greater than 100 ml, a hemoglobin of less than 12.5 g/dl. For blood draws of 100 ml or less, performed less frequently than every 56 days, a hemoglobin of less than 10.0 g/dl.
  • Current pregnancy.
  • Positive skin test to one or more allergens in the battery tested.
  • History of asthma or other allergic diseases, such as hay fever.
  • Medical history suggesting lung diseases other than asthma.
  • History of immunodeficiency or HIV infection.
  • INCLUSION CRITERIA - EXHALED BREATH CONDENSATE/ASTHMA:
  • Age 18-65.
  • Asthma as diagnosed by a physician or use of medications consistent with the treatment of asthma.
  • Subjects must have a doctor outside NIH and they will provide routine and emergency care.
  • EXCLUSION CRITERIA - EXHALED BREATH CONDENSATE/ASTHMA:
  • History of immunodeficiency or HIV infection.
  • History of allergy to latex.
  • INCLUSION CRITERIA - EXHALED BREATH CONDENSATE/HEALTHY CONTROL:
  • Age 18 - 65.
  • EXCLUSION CRITERIA - EXHALED BREATH CONDENSATE/HEALTHY CONTROL:
  • History of asthma or other allergic diseases, such as allergic rhinitis.
  • Medical history suggesting lung diseases other than asthma.
  • History of allergy to latex.
  • History of immunodeficiency or HIV infection.

Attachments

readout_NCT00001408_2023-12-10.pdf

4.5 MB

NCT00001408_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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