Genetic Analysis of Hereditary Prostate Cancer

Launched by NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI) · Nov 3, 1999

Keywords

ClinConnect Summary

Molecular approaches to the understanding of human neoplastic disease have revealed that multiple genetic alterations are an essential component of tumorigenesis. Both germline and somatic genetic alterations can be involved in the malignant transformation of normal cells. Identification of the genes involved in neoplastic transformation has been approached through the molecular analysis of sporadic cancers and the genetic study of families with an inherited predisposition for cancer. The interplay of these two approaches has led to the characterization of genes such as the retinoblastoma (...

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• Enrollment in this study includes case-control data from men with prostate cancer and matched controls who are free from the disease, plus affected and unaffected individuals from families who meet the following criteria for Hereditary Prostate Cancer:
• • 1. A cluster of 3 or more first degree relatives, such as a father and 2 sons or 3 brothers
• • 2. The occurrence of prostate cancer in each of 3 generations in either the proband's paternal or maternal lineages
• • 3. Two first or second-degree relatives affected at an early age (age 55 years or younger).