Treatment of Mid-Life-Related Mood Disorders
Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Nov 3, 1999
Trial Information
Current as of December 27, 2024
Completed
Keywords
ClinConnect Summary
Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland in concentrations that decrease with age. In humans low DHEA levels have been associated with a variety of adverse biological consequences, including increased cardiovascular disease, decreased immune function, decreased bone density, negative lipid profile and an increased fat to muscle ratio.
In this study, we investigate the effects on mood and behavior of DHEA in men and women with midlife-related mood disorders in a double-blind, placebo-controlled, crossover trial. We specifically ask whether increasing DHEA lev...
Gender
ALL
Eligibility criteria
- INCLUSION CRITERIA:
- Subjects for this study will meet the following criteria:
- • A current episode of minor (meeting 3-4 criterion symptoms) or major depression of moderate severity or less on the SCID severity scale for depression and not meeting DSM-IV criteria symptom #9 (suicide) as determined by the administration of the minor depression module of the SADS-L and the Structured Clinical Interview for DSM-IV. Additionally, to ensure that subjects meet a minimum threshold for severity of depression, subjects will have scores greater than or equal to 10 on either the Beck Depression Inventory (BDI) or the Center for Epidemiologic Studies - Depression (CES-D) Scale during at least three of the four clinic visits during the two month screening phase. Subjects will be excluded if they meet any of the following criteria: major depression of greater than moderate severity, DSM-IV criteria #9 (suicide), or anyone requiring immediate treatment after clinical assessment, functional impairment ratings of five or six for more than seven consecutive days on daily ratings;
- • Age 40-65;
- • No prior hormonal therapy for the treatment of menopause/andropause-related mood or physical symptoms within the last six months;
- • In good medical health.
- EXCLUSION CRITERIA:
- The following conditions will constitute contradictions to treatment with DHEA and will preclude a subject's participation in this protocol:
- • Positive (threshold) response to SCID major depression section item #9, suicidal ideation;
- • Anyone requiring immediate treatment after clinical assessment;
- • Severity ratings greater than moderate on the SCID;
- • Functional impairment ratings of five or six for more than seven consecutive days on daily ratings
- • Current treatment with antidepressant medications
- • Prostate nodules or cancer
- • Moderate symptoms of benign prostatic hypertrophy such as hesitancy, urgency, frequent voiding and feeling of incomplete voiding
- • History of ischemic cardiac disease
- • Renal disease
- • Hepatic dysfunction
- • Women with a history of carcinoma of the breast, or any women with a family history of the following: premenopausal breast cancer or bilateral breast cancer in a first degree relative; multiple family members (greater than three relatives) with postmenopausal breast cancer
- • Women with a history of uterine cancer
- • Patients with a known hypersensitivity to DHEA or other androgens
- • Pregnant women
About National Institute Of Mental Health (Nimh)
The National Institute of Mental Health (NIMH) is a leading federal agency dedicated to advancing the understanding and treatment of mental health disorders through innovative research and clinical trials. As part of the National Institutes of Health (NIH), NIMH focuses on a broad spectrum of mental health issues, including mood disorders, anxiety disorders, schizophrenia, and developmental disorders. By fostering collaboration among researchers, clinicians, and the community, NIMH aims to translate scientific discoveries into effective interventions and improve mental health outcomes for individuals across the lifespan. Through its commitment to rigorous research methodologies and ethical standards, NIMH plays a pivotal role in shaping the future of mental health care and policy.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bethesda, Maryland, United States
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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