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Search / Trial NCT00001523

Structure and Functional Status of Parotid Glands Exposed to Therapeutic Irradiation

Launched by NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH (NIDCR) · Dec 9, 2002

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Trial Information

Current as of January 15, 2025

Completed

Keywords

Cytology Diagnostic Imaging Radiation Damage Saliva Serostomia Xerostomia Head Cancer Neck Cancer

ClinConnect Summary

Therapeutic irradiation to the head and neck for cancer damages salivary glands present in the radiation field. Despite long recognition of radiation-induced salivary hypofunction, and the associated oral morbidities, the specific damage mechanism(s) is not known and the structure and functional integrity of the surviving parenchymal tissue has not been well-documented. Detailed knowledge of the latter is particularly necessary in order to design appropriate corrective therapies. It is the purpose of this study to provide such a detailed structural and functional assessment of human parotid...

Gender

ALL

Eligibility criteria

  • • Age 21-80.
  • • Diagnosis of head and neck cancer.
  • • No surgery OR surgery with parotid glands intact.
  • • Therapeutic radiation greater than or equal to 52 Gy.
  • • Ambulatory.
  • • No OR limited chemotherapy.
  • • No Metastasis.
  • • No allergy to Iodine.
  • • No allergy to shellfish.
  • • No metallic implants in head or neck.
  • • No history of bleeding disorder.
  • • No previous history of dry mouth (xerostomia).
  • • No history of Sjogren's syndrome.
  • • Negative HIV.

About National Institute Of Dental And Craniofacial Research (Nidcr)

The National Institute of Dental and Craniofacial Research (NIDCR) is a pivotal component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of dental and craniofacial disorders. Through innovative research and clinical trials, NIDCR aims to enhance oral health and improve the quality of life for individuals affected by these conditions. The institute fosters collaboration among scientists, clinicians, and public health professionals to translate research findings into practical applications, ensuring that the latest advancements benefit patients and communities. With a commitment to excellence in research and education, NIDCR plays a critical role in shaping the future of oral health care.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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