Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Keywords

ClinConnect Summary

Wegener's granulomatosis is a systemic vasculitis in which parenchymal and/or endobronchial inflammation frequently occur. The purpose of this investigation is to analyze bronchial and bronchoalveolar lavage fluid in patients with Wegener's granulomatosis for the presence of immunoregulatory mediators and pro-inflammatory cytokines. We will also be examining mucosal biopsies in these patients to define the histologic changes, the phenotype of infiltrating leukocytes, and the pattern of adhesion molecule expression that may be present. Such studies could lead to an improved understanding of ...

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Eligibility criteria

• INCLUSION CRITERIA:
• • Diagnosis of Wegener's granulomatosis based on clinical and histological characteristics.
• • Age between 18-75 years.
• • Bronchoscopy is required as part of their standard medical care.
• • FEV1 is greater than 55 percent of FVC.
• • O2 saturation is greater than 90 percent.
• EXCLUSION CRITERIA:
• • FEV1 is less than 55% of FVC.
• • O2 saturation is less than 90%.
• • Abnormal PT, PTT, or platelet count less than 50.
• • History of adverse reaction to lidocaine or other local anesthetics.
• • Pregnancy.