Nctid:
NCT00001601
Payload:
{"FullStudy"=>{"Rank"=>497817, "Study"=>{"DerivedSection"=>{"MiscInfoModule"=>{"VersionHolder"=>"June 24, 2024"}, "ConditionBrowseModule"=>{"ConditionMeshList"=>{"ConditionMesh"=>[{"ConditionMeshId"=>"D000013705", "ConditionMeshTerm"=>"Temporomandibular Joint Disorders"}, {"ConditionMeshId"=>"D000013706", "ConditionMeshTerm"=>"Temporomandibular Joint Dysfunction Syndrome"}, {"ConditionMeshId"=>"D000013280", "ConditionMeshTerm"=>"Stomatitis"}, {"ConditionMeshId"=>"D000009059", "ConditionMeshTerm"=>"Mouth Diseases"}, {"ConditionMeshId"=>"D000002054", "ConditionMeshTerm"=>"Burning Mouth Syndrome"}, {"ConditionMeshId"=>"D000013281", "ConditionMeshTerm"=>"Stomatitis, Aphthous"}, {"ConditionMeshId"=>"D000008010", "ConditionMeshTerm"=>"Lichen Planus"}, {"ConditionMeshId"=>"D000002056", "ConditionMeshTerm"=>"Burns"}]}, "ConditionAncestorList"=>{"ConditionAncestor"=>[{"ConditionAncestorId"=>"D000017512", "ConditionAncestorTerm"=>"Lichenoid Eruptions"}, {"ConditionAncestorId"=>"D000017444", "ConditionAncestorTerm"=>"Skin Diseases, Papulosquamous"}, {"ConditionAncestorId"=>"D000012871", "ConditionAncestorTerm"=>"Skin Diseases"}, {"ConditionAncestorId"=>"D000007592", "ConditionAncestorTerm"=>"Joint Diseases"}, {"ConditionAncestorId"=>"D000009140", "ConditionAncestorTerm"=>"Musculoskeletal Diseases"}, {"ConditionAncestorId"=>"D000017271", "ConditionAncestorTerm"=>"Craniomandibular Disorders"}, {"ConditionAncestorId"=>"D000008336", "ConditionAncestorTerm"=>"Mandibular Diseases"}, {"ConditionAncestorId"=>"D000007571", "ConditionAncestorTerm"=>"Jaw Diseases"}, {"ConditionAncestorId"=>"D000009135", "ConditionAncestorTerm"=>"Muscular Diseases"}, {"ConditionAncestorId"=>"D000009057", "ConditionAncestorTerm"=>"Stomatognathic Diseases"}, {"ConditionAncestorId"=>"D000009209", "ConditionAncestorTerm"=>"Myofascial Pain Syndromes"}, {"ConditionAncestorId"=>"D000014947", "ConditionAncestorTerm"=>"Wounds and Injuries"}]}, "ConditionBrowseLeafList"=>{"ConditionBrowseLeaf"=>[{"ConditionBrowseLeafId"=>"M10621", "ConditionBrowseLeafName"=>"Joint Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M16477", "ConditionBrowseLeafName"=>"Temporomandibular Joint Disorders", "ConditionBrowseLeafAsFound"=>"Temporomandibular Joint Disorders", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M16478", "ConditionBrowseLeafName"=>"Temporomandibular Joint Dysfunction Syndrome", "ConditionBrowseLeafAsFound"=>"Temporomandibular Joint Disorders", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M16355", "ConditionBrowseLeafName"=>"Syndrome", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M17206", "ConditionBrowseLeafName"=>"Ulcer", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12019", "ConditionBrowseLeafName"=>"Mouth Diseases", "ConditionBrowseLeafAsFound"=>"Mouth Disease", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M11012", "ConditionBrowseLeafName"=>"Lichen Planus", "ConditionBrowseLeafAsFound"=>"Lichen Planus", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M16070", "ConditionBrowseLeafName"=>"Stomatitis", "ConditionBrowseLeafAsFound"=>"Stomatitis", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M5326", "ConditionBrowseLeafName"=>"Burns", "ConditionBrowseLeafAsFound"=>"Burning", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M16071", "ConditionBrowseLeafName"=>"Stomatitis, Aphthous", "ConditionBrowseLeafAsFound"=>"Aphthous Stomatitis", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M5324", "ConditionBrowseLeafName"=>"Burning Mouth Syndrome", "ConditionBrowseLeafAsFound"=>"Burning Mouth Syndrome", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M12841", "ConditionBrowseLeafName"=>"Oral Manifestations", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M19775", "ConditionBrowseLeafName"=>"Lichenoid Eruptions", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M8219", "ConditionBrowseLeafName"=>"Exanthema", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M15674", "ConditionBrowseLeafName"=>"Skin Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M19713", "ConditionBrowseLeafName"=>"Skin Diseases, Papulosquamous", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12097", "ConditionBrowseLeafName"=>"Musculoskeletal Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M19566", "ConditionBrowseLeafName"=>"Craniomandibular Disorders", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M11327", "ConditionBrowseLeafName"=>"Mandibular Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M10601", "ConditionBrowseLeafName"=>"Jaw Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12092", "ConditionBrowseLeafName"=>"Muscular Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12017", "ConditionBrowseLeafName"=>"Stomatognathic Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M8486", "ConditionBrowseLeafName"=>"Fibromyalgia", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12161", "ConditionBrowseLeafName"=>"Myofascial Pain Syndromes", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M13066", "ConditionBrowseLeafName"=>"Pain", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M17685", "ConditionBrowseLeafName"=>"Wounds and Injuries", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"T455", "ConditionBrowseLeafName"=>"Aphthous Stomatitis", "ConditionBrowseLeafAsFound"=>"Aphthous Stomatitis", "ConditionBrowseLeafRelevance"=>"high"}]}, "ConditionBrowseBranchList"=>{"ConditionBrowseBranch"=>[{"ConditionBrowseBranchName"=>"Musculoskeletal Diseases", "ConditionBrowseBranchAbbrev"=>"BC05"}, {"ConditionBrowseBranchName"=>"All Conditions", "ConditionBrowseBranchAbbrev"=>"All"}, {"ConditionBrowseBranchName"=>"Mouth and Tooth Diseases", "ConditionBrowseBranchAbbrev"=>"BC07"}, {"ConditionBrowseBranchName"=>"Symptoms and General Pathology", "ConditionBrowseBranchAbbrev"=>"BC23"}, {"ConditionBrowseBranchName"=>"Skin and Connective Tissue Diseases", "ConditionBrowseBranchAbbrev"=>"BC17"}, {"ConditionBrowseBranchName"=>"Wounds and Injuries", "ConditionBrowseBranchAbbrev"=>"BC26"}, {"ConditionBrowseBranchName"=>"Nervous System Diseases", "ConditionBrowseBranchAbbrev"=>"BC10"}, {"ConditionBrowseBranchName"=>"Rare Diseases", "ConditionBrowseBranchAbbrev"=>"Rare"}]}}}, "ProtocolSection"=>{"DesignModule"=>{"PhaseList"=>{"Phase"=>["Not Applicable"]}, "StudyType"=>"Interventional", "EnrollmentInfo"=>{"EnrollmentCount"=>"999"}}, "StatusModule"=>{"OverallStatus"=>"Completed", "StartDateStruct"=>{"StartDate"=>"August 1997"}, "ExpandedAccessInfo"=>{"HasExpandedAccess"=>"No"}, "StatusVerifiedDate"=>"August 2002", "CompletionDateStruct"=>{"CompletionDate"=>"August 2002"}, "LastUpdateSubmitDate"=>"March 3, 2008", "StudyFirstSubmitDate"=>"November 3, 1999", "StudyFirstSubmitQCDate"=>"November 3, 1999", "LastUpdatePostDateStruct"=>{"LastUpdatePostDate"=>"March 4, 2008", "LastUpdatePostDateType"=>"Estimate"}, "StudyFirstPostDateStruct"=>{"StudyFirstPostDate"=>"November 4, 1999", "StudyFirstPostDateType"=>"Estimate"}}, "OversightModule"=>{}, "ConditionsModule"=>{"KeywordList"=>{"Keyword"=>["Oral Medicine", "Clinical Experience", "Therapy", "Educational Training", "Pathogenesis", "Oral Lesions", "Aphthous Ulcers", "Lichen Planus", "Burning Mouth", "Temporomandibular Dysfunction (TMD)", "Oral Disease", "Oral Manifestations"]}, "ConditionList"=>{"Condition"=>["Aphthous Stomatitis", "Burning Mouth Syndrome", "Lichen Planus", "Mouth Disease", "Temporomandibular Joint Disorder"]}}, "ReferencesModule"=>{"ReferenceList"=>{"Reference"=>[{"ReferencePMID"=>"9421218", "ReferenceType"=>"background", "ReferenceCitation"=>"Lozada-Nur F, Miranda C. Oral lichen planus: epidemiology, clinical characteristics, and associated diseases. Semin Cutan Med Surg. 1997 Dec;16(4):273-7. doi: 10.1016/s1085-5629(97)80016-8."}, {"ReferencePMID"=>"8667255", "ReferenceType"=>"background", "ReferenceCitation"=>"Axell T, Pindborg JJ, Smith CJ, van der Waal I. Oral white lesions with special reference to precancerous and tobacco- related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions. J Oral Pathol Med. 1996 Feb;25(2):49-54. doi: 10.1111/j.1600-0714.1996.tb00191.x."}, {"ReferencePMID"=>"8665304", "ReferenceType"=>"background", "ReferenceCitation"=>"Ship JA. Recurrent aphthous stomatitis. An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Feb;81(2):141-7. doi: 10.1016/s1079-2104(96)80403-3."}]}}, "DescriptionModule"=>{"BriefSummary"=>"This study offers evaluation and treatment of patients with diseases of the mouth or systemic diseases that involve the mouth. The protocol is not designed to test new treatments; rather, patients will receive current standard of care treatments. The purposes of the study are: 1) to allow NIDCR's Gene Therapy and Therapeutics Branch staff to gain more knowledge about oral soft tissue diseases and possibly identify new avenues of research in this area; and 2) to establish a pool of patients who may be eligible for new studies as they are developed. (Participants in this protocol will not be required to join a new study; the decision will be voluntary.)\n\nPatients of any age with oral diseases or systemic diseases involving the mouth may be eligible for this study. Women of childbearing potential and women who are pregnant or breastfeeding will only have tests and procedures and receive medications that pose no greater than a minimal risk to the fetus.\n\nParticipants will have a comprehensive dental and medical examination, including a physical examination of the head and neck. Additional tests and procedures that may be required for diagnosis and to guide treatment include the following:\n\nBlood and urine tests - for routine laboratory studies, assessment of kidney and liver function, and detection of viruses, fungi, bacteria or parasites\nElectrocardiogram - to record the electrical activity of the heart\nBiopsies - to examine tissue under the microscope. The method and number of biopsies depends on the individual's specific condition and the tissue to be removed. For all biopsies a local anesthetic (lidocaine with or without epinephrine) is injected at the biopsy site. A punch biopsy uses a small sharp cookie-cutter instrument to remove a small (about 1/10- to 1/5-inch) piece of skin. An excisional biopsy uses a small surgical knife or scalpel to remove a piece of tissue, usually requiring some stitches to close the wound.\nDiagnostic imaging - X-rays, photographs, or other tests as needed for diagnosis\n\nTreatments include tablets, injections and topically applied medications. All preparations are approved by the Food and Drug Administration and are commercially available. Patient follow-up may vary from one visit to intermittent visits over a number of years, depending on the patient's condition.", "DetailedDescription"=>"The function of this protocol is to support the training of residents in Oral Medicine in the management of oral soft tissue diseases. Patients enrolled in this protocol will be evaluated and treated according to available standard procedures and therapeutic modalities. Samples of blood and oral tissues will be studied by routine and specialized investigative methods to establish the diagnoses, responses to treatment, and/or disease progression."}, "EligibilityModule"=>{"Gender"=>"All", "StdAgeList"=>{"StdAge"=>["Child", "Adult", "Older Adult"]}, "HealthyVolunteers"=>"No", "EligibilityCriteria"=>"INCLUSION CRITERIA\n\nPatients of any age, both genders, and all racial/ethnic groups with oral diseases or systemic diseases with oral manifestations that will help the branch fulfill the objectives listed in Section 1.0.\n\nWomen of childbearing potential, or who are pregnant or lactating, will only undergo tests and procedures, and/or receive medications for which data exists proving minimal risk to the fetus and/or child. Only diagnosis without radiographs will be performed.\n\nEXCLUSION CRITERIA\n\nA written referral is needed from the patient's physician or dentist.\n\nNo patients with significant cognitive impairment.\n\nNo pregnancy or lactation, if this status precludes proposed diagnostic procedures or therapies because of unknown, untoward effects on mother and/or child."}, "IdentificationModule"=>{"NCTId"=>"NCT00001601", "BriefTitle"=>"Evaluation and Treatment of Oral Soft Tissue Diseases", "Organization"=>{"OrgClass"=>"NIH", "OrgFullName"=>"National Institutes of Health Clinical Center (CC)"}, "OfficialTitle"=>"Patient Evaluation and Treatment of Oral Soft Tissue Diseases According to Generally Available, Standard Procedures and Therapeutic Modalities", "OrgStudyIdInfo"=>{"OrgStudyId"=>"970169"}, "SecondaryIdInfoList"=>{"SecondaryIdInfo"=>[{"SecondaryId"=>"97-D-0169"}]}}, "ArmsInterventionsModule"=>{"InterventionList"=>{"Intervention"=>[{"InterventionName"=>"Electrocardiogram", "InterventionType"=>"Procedure"}, {"InterventionName"=>"Biopsies", "InterventionType"=>"Procedure"}, {"InterventionName"=>"Diagnostic imaging", "InterventionType"=>"Procedure"}]}}, "ContactsLocationsModule"=>{"LocationList"=>{"Location"=>[{"LocationZip"=>"20892", "LocationCity"=>"Bethesda", "LocationState"=>"Maryland", "LocationCountry"=>"United States", "LocationFacility"=>"National Institute of Dental And Craniofacial Research (NIDCR)"}]}}, "SponsorCollaboratorsModule"=>{"LeadSponsor"=>{"LeadSponsorName"=>"National Institute of Dental and Craniofacial Research (NIDCR)", "LeadSponsorClass"=>"NIH"}}}}}}
