Genetic Analysis of Parkinson's Disease

Launched by NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI) · Nov 3, 1999

Keywords

ClinConnect Summary

Individuals, and where possible multiple family members, from families with inherited Parkinson's disease will be enrolled. We will also be enrolling people with sporadic Parkinson's disease. Known disease genes will be sequenced to look for mutations. In the event that no mutations are detected and there are samples from multiple family members, linkage analysis will be undertaken in an effort to identify a region or regions of the genome harboring defective genes that cause inherited Parkinson's disease. Candidate genes that reside in regions linked to the disease will be sequenced in eff...

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Individuals age 18 or over from families in which an autosomal dominant form of Parkinson's disease is apparently being inherited.
• • The diagnosis must be supported by accepted clinical criteria: tremor, bradykinesia, and responsiveness to L-DOPA.
• • Unaffected family members will also be enrolled.
• • Subjects must give consent.
• • Parkinson's disease may be associated with dementia.
• • Decisionally-impaired individuals will be enrolled.