Search / Trial NCT00001640

Genetic Analysis of Parkinson's Disease

Launched by NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI) · Nov 3, 1999

Trial Information

Current as of December 14, 2024

Completed

Keywords

Parkinson's Disease

ClinConnect Summary

Individuals, and where possible multiple family members, from families with inherited Parkinson's disease will be enrolled. We will also be enrolling people with sporadic Parkinson's disease. Known disease genes will be sequenced to look for mutations. In the event that no mutations are detected and there are samples from multiple family members, linkage analysis will be undertaken in an effort to identify a region or regions of the genome harboring defective genes that cause inherited Parkinson's disease. Candidate genes that reside in regions linked to the disease will be sequenced in eff...

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Individuals age 18 or over from families in which an autosomal dominant form of Parkinson's disease is apparently being inherited.
  • The diagnosis must be supported by accepted clinical criteria: tremor, bradykinesia, and responsiveness to L-DOPA.
  • Unaffected family members will also be enrolled.
  • Subjects must give consent.
  • Parkinson's disease may be associated with dementia.
  • Decisionally-impaired individuals will be enrolled.

About National Human Genome Research Institute (Nhgri)

The National Human Genome Research Institute (NHGRI) is a prominent research organization within the National Institutes of Health (NIH) dedicated to advancing the field of genomics and its applications in health and medicine. NHGRI sponsors and conducts a wide range of clinical trials aimed at understanding the genetic basis of diseases, developing innovative genomic technologies, and translating genomic research into clinical practice. With a commitment to ethical research and collaboration, NHGRI plays a pivotal role in shaping the future of personalized medicine and improving patient outcomes through genomic discoveries.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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