Search / Trial NCT00001726

Study of the Composition of Dental Plaque

Launched by NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH (NIDCR) · Nov 3, 1999

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Trial Information

Current as of March 02, 2024

Completed

Keywords

Bacterial Colonization Plaque Mouth Saliva Adhesion Dental Plaque Formation Dental Caries

Description

Dental caries and periodontal disease are closely associated with dental plaque, the biofilm that results from microbial colonization of the tooth surface. Various experimental models have been described for the initial phase of colonization, including one that utilizes enamel chips positioned within the oral cavity for periods of time up to 24 hours. Scanning electron microscopy of chips removed after 4 hrs in vivo revealed individual bacteria attached to the pellicle-coated surface. Growth of these pioneer organisms resulted in microcolonies that merged to form a spreading monolayer of co...

Gender

All

Eligibility criteria

  • INCLUSION CRITERIA:
  • Aged 18 to 65 years
  • EXCLUSION CRITERIA:
  • History of medical conditions affecting salivary flow.
  • History of immunosuppressant therapy.
  • Use of tobacco.
  • Use of antibiotics within the preceding four months.
  • Use of medications thought to affect salivary flow.
  • Missing any maxillary premolar, first, or second molar.
  • Unwilling or unable to give informed consent.

Attachments

readout_NCT00001726_2024-03-02.pdf

4.5 MB

NCT00001726_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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