Search / Trial NCT00001726

Study of the Composition of Dental Plaque

Launched by NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH (NIDCR) · Nov 3, 1999

Trial Information

Current as of December 26, 2024

Completed

Keywords

Bacterial Colonization Plaque Mouth Saliva Adhesion Dental Plaque Formation Dental Caries

ClinConnect Summary

Dental caries and periodontal disease are closely associated with dental plaque, the biofilm that results from microbial colonization of the tooth surface. Various experimental models have been described for the initial phase of colonization, including one that utilizes enamel chips positioned within the oral cavity for periods of time up to 24 hours. Scanning electron microscopy of chips removed after 4 hrs in vivo revealed individual bacteria attached to the pellicle-coated surface. Growth of these pioneer organisms resulted in microcolonies that merged to form a spreading monolayer of co...

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Aged 18 to 65 years
  • EXCLUSION CRITERIA:
  • History of medical conditions affecting salivary flow.
  • History of immunosuppressant therapy.
  • Use of tobacco.
  • Use of antibiotics within the preceding four months.
  • Use of medications thought to affect salivary flow.
  • Missing any maxillary premolar, first, or second molar.
  • Unwilling or unable to give informed consent.

About National Institute Of Dental And Craniofacial Research (Nidcr)

The National Institute of Dental and Craniofacial Research (NIDCR) is a pivotal component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of dental and craniofacial disorders. Through innovative research and clinical trials, NIDCR aims to enhance oral health and improve the quality of life for individuals affected by these conditions. The institute fosters collaboration among scientists, clinicians, and public health professionals to translate research findings into practical applications, ensuring that the latest advancements benefit patients and communities. With a commitment to excellence in research and education, NIDCR plays a critical role in shaping the future of oral health care.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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