Current as of December 10, 2023
The endothelium modulates vascular tone by the release of constricting and relaxing substances that act on the underlying smooth muscle. This regulatory activity of the endothelium is dysfunctional in a number of cardiovascular conditions, including essential hypertension and hypercholesterolemia. Previous studies from our group have implicated a decreased action of endothelium-derived nitric oxide (NO) as the mechanism responsible for this abnormality. Whether this reduced bioactivity of NO is related to vasoactive prostanoids remains uncertain. We propose to test the hypothesis that an i...
- Patients (men and nonpregnant women) with systemic hypertension and patients with hypercholesterolema will be included for this study.
- Patient with aspirin allergies and those with a platelet count less than 50,000 will be excluded.
- Volunteers cannot be in any kind of medication while participating in this study.
- No history of diabetes, peripheral vascular disease, coagulopathy, or vasculitis.
- Must be capable of rendering informed consent for all procedures.
The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, Maryland, United States
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