The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Dec 9, 2002

Keywords

ClinConnect Summary

The endothelium modulates vascular tone by the release of constricting and relaxing substances that act on the underlying smooth muscle. This regulatory activity of the endothelium is dysfunctional in a number of cardiovascular conditions, including essential hypertension and hypercholesterolemia. Previous studies from our group have implicated a decreased action of endothelium-derived nitric oxide (NO) as the mechanism responsible for this abnormality. Whether this reduced bioactivity of NO is related to vasoactive prostanoids remains uncertain.

We propose to test the hypothesis that an i...

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Eligibility criteria

• • Patients (men and nonpregnant women) with systemic hypertension and patients with hypercholesterolema will be included for this study.
• • Patient with aspirin allergies and those with a platelet count less than 50,000 will be excluded.
• • Volunteers cannot be in any kind of medication while participating in this study.
• • No history of diabetes, peripheral vascular disease, coagulopathy, or vasculitis.
• • Must be capable of rendering informed consent for all procedures.