Search / Trial NCT00001760

Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Trial Information

Current as of December 26, 2024

Completed

Keywords

Stem Cell Factor Cytokine Chemokines Chemotaxis Mast Cells Normal Volunteer Systemic Mastocytosis Atopic Dermatitis

ClinConnect Summary

Systemic mastocytosis is a disease characterized by an abnormal accumulation of mast cells in skin, bone marrow and viscera. Precise mechanisms of events leading to the migration and proliferation of mast cells in skin is not known. We propose to investigate the in vivo cytokine and chemokine production patterns of human skin in patients with mastocytosis and compare these findings to those of patients with atopic dermatitis and to healthy volunteers, using the suction blister technique. The cytokines/chemokines of interest in this study are stem cell factor (SCF), interleukin (IL)-3, IL-4,...

Gender

ALL

Eligibility criteria

  • General: Age equal to or greater than 18.
  • Access to a primary medical care provider outside of the NIH.
  • Able to give informed consent.
  • No history of malignancy or autoimmune disease such as rheumatoid arthritis, vasculitis, pyoderma gangrenosum, psoriasis.
  • No use of systemic corticosteroids within the past month.
  • No use of local corticosteroids at the proposed blistering site within the past month.
  • No evidence of current acute infection.
  • INR less than or equal to 1.5, PTT less than or equal to 40, platelet count greater than or equal to 100,000/mm(3).
  • No personal or family history of keloid formation.
  • Blood glucose less than or equal to 160.
  • No use of any investigative drugs within the past month.
  • No allergy to lidocaine.
  • Healthy volunteers must not have a history of atopic dermatitis, mastocytosis or chronic urticaria.
  • Mastocytosis: Histologic evidence of mast cell hyperplasia in at least one organ system.
  • Atopic Dermatitis: Must have at least 3 major and 3 minor criteria.
  • No history of mastocytosis.

About National Institute Of Allergy And Infectious Diseases (Niaid)

The National Institute of Allergy and Infectious Diseases (NIAID) is a key component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of infectious and immune-mediated diseases. Through rigorous clinical trials, NIAID aims to foster innovative research that enhances public health and addresses global health challenges, including emerging infectious diseases and allergies. The institute collaborates with various partners, including academic institutions, industry, and international organizations, to translate scientific discoveries into effective therapies and vaccines. NIAID's commitment to high-quality clinical research is integral to improving health outcomes and informing policy decisions in the realm of infectious diseases and immunology.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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