Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus

Launched by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) · Jan 26, 2000

Keywords

ClinConnect Summary

Genetic variations in CD152 have been reported to confer susceptibility to the development of type-1-diabetes mellitus (T1DM). In this protocol we will draw blood samples from patients and normal control volunteers in order to analyze for the presence of CD152 genetic variations and to determine whether those variations are associated with measurable abnormalities in T cell function. Subjects with T1DM and homozygous CD152 gene polymorphisms, patients with T1DM but without CD152 polymorphisms, and control subjects with or without CD152 polymorphisms will be studied to determine whether the ...

Gender

ALL

Eligibility criteria

• • Patients must have a willingness and legal ability to give consent, or permission.
• • Candidates with T1DM or Healthy Volunteers will be eligible.
• • Patients must be equal to or greater than 18 years of age.
• • Patients must not have an active malignancy.
• • Patients with a hemoglobin count of less than 9.0 mg/dl will be excluded. Patients may be on erythropoietin therapy, but will not be placed on therapy solely to facilitate research sample acquisition.
• • Patients must not have a known immunodeficiency syndrome.