The Antiviral Efficacy of Concurrent Zidovudine and 2',3'-Dideoxyinosine or 2',3'-Dideoxycytidine in Patients With Human Immunodeficiency Virus Disease
Launched by GLAXO WELLCOME · Aug 30, 2001
Trial Information
Current as of July 06, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- Concurrent Medication:
- Allowed:
- • Patients with PCP may be randomized to study medication after contacting the sponsor and following a minimum 7-day course of therapy resulting in stabilization of their disease. Patients with stabilized disease must have fever \< 39 C for at least 48 hours, p02 (on room air) \> or = 60 mm and an A/A gradient \< or = 30 mm.
- • Prophylaxis for PCP.
- Patients must have the following:
- • HIV-1 seropositive by any federally licensed ELISA.
- • Willingness to give informed consent.
- • Exclusion Criteria
- Co-existing Condition:
- Patients with the following conditions or symptoms are excluded:
- • Any immediately life-threatening infection or medical condition present at time of study entry.
- • Any active opportunistic infection requiring chronic therapy with any of the agents listed in the exclusion concurrent medication section.
- • Neoplasms other than basal cell carcinoma or in situ carcinoma of the cervix.
- • Kaposi's sarcoma with visceral involvement or requiring systemic cytotoxic chemotherapy.
- • AIDS dementia complex, \> or = Stage 2.
- • History of zidovudine induced toxicity.
- • Prior history of acute pancreatitis during the past two years or chronic pancreatitis.
- • Grade 2 neuropathy.
- • Intractable diarrhea.
- • History of seizures within the past six months or current requirement of anticonvulsants.
- • Past or current heart disease.
- • Fever \> 39 C at entry.
- Concurrent Medication:
- • Current requirement of anticonvulsants.
- * Excluded:
- • It is intended that patients developing new opportunistic infections during the course of the study will continue study participation, unless required therapy is associated with significant neurologic or hematologic toxicities, in which case the study medication may be temporarily discontinued.
- • Ganciclovir.
- • Chloramphenicol.
- • Cisplatinum.
- • Iodoquinol.
- • Systemic Pentamidine.
- • Disulfiram.
- • Ethionamide.
- • Glutethimide.
- • Gold.
- • Hydralazine.
- • Metronidazole.
- • Sodium Cyanate.
- • Thalidomide.
- • Vincristine.
- • Allopurinol.
- • Probenecid.
- Concurrent Treatment:
- Excluded:
- • Radiation therapy. (with the exception of electron beam therapy to an area of \< 100cm/m2.)
- Patients with the following are excluded:
- • Any immediately life-threatening infection or medical condition present at time of study entry.
- • Any active opportunistic infection requiring chronic therapy with any of the agents listed in the exclusion concurrent medication section.
- • Active alcohol or drug abuse, sufficient in the investigator's opinion to prevent compliance with study therapy.
- • Neoplasms other than basal cell carcinoma or in situ carcinoma of the cervix.
- • Kaposi's syndrome with visceral involvement or requiring systemic cytotoxic chemotherapy.
- • AIDS dementia complex, \> or = Stage 2.
- • History of zidovudine induced toxicity.
- • Any experimental therapy within 30 days.
- • Prior history of acute pancreatitis during the past two years or chronic pancreatitis.
- • Grade 2 neuropathy.
- • Intractable diarrhea.
- • History of seizures within the past six months or current requirement of anticonvulsants.
- • History of past or current heart disease.
- • Fever \> 39 C at entry.
- Prior Medication:
- Excluded:
- • Any anti-HIV therapy (other than zidovudine), biologic response modifiers, or pharmacologic doses of corticosteroids within eight weeks of entry (except for the management of severe PCP, in which case duration is not to exceed 21 days).
- • Zidovudine therapy for greater than four weeks or prior discontinuation due to drug toxicity.
- • Prior therapy with ddI, ddC, D4T, or interferon.
- • Any experimental therapy within 30 days.
- • Therapy within 30 days with neurotoxic drugs.
- Prior Treatment:
- Excluded:
- • Radiation therapy within two weeks of entry or likely to require radiation therapy (with the exception of electron beam therapy to an area of \< 100cm/m2).
- • Active alcohol or drug abuse, sufficient in the investigator's opinion, to prevent compliance with study therapy.
About Glaxo Wellcome
Glaxo Wellcome, a leading global biopharmaceutical company, is dedicated to advancing healthcare through innovative research and development of new therapies. With a strong focus on addressing unmet medical needs, Glaxo Wellcome combines scientific excellence with a commitment to improving patient outcomes across various therapeutic areas, including respiratory, infectious diseases, and oncology. The company is recognized for its robust clinical trial portfolio, leveraging cutting-edge technology and collaborative partnerships to drive the development of transformative treatments. Glaxo Wellcome upholds the highest ethical standards in clinical research, ensuring patient safety and integrity throughout the trial process.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
San Juan, , Puerto Rico
Denver, Colorado, United States
Darlinghurst, , Australia
Nashville, Tennessee, United States
Washington, District Of Columbia, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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