Nctid:
NCT00002084
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-12-04"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D007239", "term"=>"Infections"}, {"id"=>"D003141", "term"=>"Communicable Diseases"}, {"id"=>"D006561", "term"=>"Herpes Simplex"}, {"id"=>"D006566", "term"=>"Herpesviridae Infections"}], "ancestors"=>[{"id"=>"D020969", "term"=>"Disease Attributes"}, {"id"=>"D010335", "term"=>"Pathologic Processes"}, {"id"=>"D014777", "term"=>"Virus Diseases"}, {"id"=>"D004266", "term"=>"DNA Virus Infections"}, {"id"=>"D017193", "term"=>"Skin Diseases, Viral"}, {"id"=>"D012874", "term"=>"Skin Diseases, Infectious"}, {"id"=>"D012871", "term"=>"Skin Diseases"}], "browseLeaves"=>[{"id"=>"M16355", "name"=>"Syndrome", "relevance"=>"LOW"}, {"id"=>"M10283", "name"=>"Infections", "asFound"=>"Infection", "relevance"=>"HIGH"}, {"id"=>"M6368", "name"=>"Communicable Diseases", "asFound"=>"Infection", "relevance"=>"HIGH"}, {"id"=>"M18250", "name"=>"HIV Infections", "relevance"=>"LOW"}, {"id"=>"M9639", "name"=>"Herpes Simplex", "asFound"=>"Herpes Simplex", "relevance"=>"HIGH"}, {"id"=>"M9636", "name"=>"Herpes Genitalis", "relevance"=>"LOW"}, {"id"=>"M10199", "name"=>"Immunologic Deficiency Syndromes", "relevance"=>"LOW"}, {"id"=>"M3522", "name"=>"Acquired Immunodeficiency Syndrome", "relevance"=>"LOW"}, {"id"=>"M9643", "name"=>"Herpesviridae Infections", "asFound"=>"Herpes Infection", "relevance"=>"HIGH"}, {"id"=>"M4320", "name"=>"Anus Diseases", "relevance"=>"LOW"}, {"id"=>"M3735", "name"=>"AIDS-Related Complex", "relevance"=>"LOW"}, {"id"=>"M22700", "name"=>"Disease Attributes", "relevance"=>"LOW"}, {"id"=>"M17522", "name"=>"Virus Diseases", "relevance"=>"LOW"}, {"id"=>"M7442", "name"=>"DNA Virus Infections", "relevance"=>"LOW"}, {"id"=>"M15674", "name"=>"Skin Diseases", "relevance"=>"LOW"}, {"id"=>"M19501", "name"=>"Skin Diseases, Viral", "relevance"=>"LOW"}, {"id"=>"M15677", "name"=>"Skin Diseases, Infectious", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Symptoms and General Pathology", "abbrev"=>"BC23"}, {"name"=>"All Conditions", "abbrev"=>"All"}, {"name"=>"Infections", "abbrev"=>"BC01"}, {"name"=>"Urinary Tract, Sexual Organs, and Pregnancy Conditions", "abbrev"=>"BXS"}, {"name"=>"Immune System Diseases", "abbrev"=>"BC20"}, {"name"=>"Skin and Connective Tissue Diseases", "abbrev"=>"BC17"}, {"name"=>"Digestive System Diseases", "abbrev"=>"BC06"}]}, "interventionBrowseModule"=>{"meshes"=>[{"id"=>"D000077483", "term"=>"Valacyclovir"}, {"id"=>"D000212", "term"=>"Acyclovir"}], "ancestors"=>[{"id"=>"D000998", "term"=>"Antiviral Agents"}, {"id"=>"D000890", "term"=>"Anti-Infective Agents"}], "browseLeaves"=>[{"id"=>"M3567", "name"=>"Acyclovir", "asFound"=>"Polysaccharide", "relevance"=>"HIGH"}, {"id"=>"M1809", "name"=>"Valacyclovir", "asFound"=>"385", "relevance"=>"HIGH"}, {"id"=>"M4314", "name"=>"Antiviral Agents", "relevance"=>"LOW"}, {"id"=>"M4214", "name"=>"Anti-Infective Agents", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Anti-Infective Agents", "abbrev"=>"Infe"}, {"name"=>"All Drugs and Chemicals", "abbrev"=>"All"}]}}, "protocolSection"=>{"designModule"=>{"phases"=>["NA"], "studyType"=>"INTERVENTIONAL", "designInfo"=>{"primaryPurpose"=>"TREATMENT"}}, "statusModule"=>{"overallStatus"=>"COMPLETED", "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"1996-04", "lastUpdateSubmitDate"=>"2005-06-23", "studyFirstSubmitDate"=>"1999-11-02", "studyFirstSubmitQcDate"=>"2001-08-30", "lastUpdatePostDateStruct"=>{"date"=>"2005-06-24", "type"=>"ESTIMATED"}, "studyFirstPostDateStruct"=>{"date"=>"2001-08-31", "type"=>"ESTIMATED"}}, "conditionsModule"=>{"keywords"=>["Acyclovir", "Acquired Immunodeficiency Syndrome", "AIDS-Related Complex", "Antiviral Agents", "Anus Diseases", "Herpes Genitalis"], "conditions"=>["Herpes Simplex", "HIV Infections"]}, "descriptionModule"=>{"briefSummary"=>"To determine the safety and efficacy of oral valacyclovir hydrochloride ( 256U87 ) compared to acyclovir in the treatment of recurrent anogenital herpes in HIV-infected patients with CD4 counts = or \\> 100 cells/mm3."}, "eligibilityModule"=>{"sex"=>"ALL", "stdAges"=>["ADULT", "OLDER_ADULT"], "minimumAge"=>"18 years", "healthyVolunteers"=>false, "eligibilityCriteria"=>"Inclusion Criteria\n\nPatients must have:\n\n* HIV infection with CD4 counts = or \\> 100 cells/mm3.\n* Documented culture of anogenital herpes simplex virus (HSV) within the last 5 years.\n* History of recurrent anogenital HSV infection, with a recurrence (with or without culture) within 1 year prior to study.\n\nExclusion Criteria\n\nCo-existing Condition:\n\nPatients with the following symptoms and conditions are excluded:\n\n* Malabsorption or vomiting that would potentially limit the retention and absorption of oral therapy.\n\nConcurrent Medication:\n\nExcluded:\n\n* Systemic antiherpes medication.\n* Interferon.\n\nPatients with the following prior conditions are excluded:\n\nHistory of hypersensitivity to acyclovir."}, "identificationModule"=>{"nctId"=>"NCT00002084", "briefTitle"=>"A Comparative Trial of Valacyclovir Hydrochloride ( 256U87 ) and Acyclovir for the Suppression of Anogenital Herpes Infections in HIV-Infected Patients", "organization"=>{"class"=>"INDUSTRY", "fullName"=>"NIH AIDS Clinical Trials Information Service"}, "officialTitle"=>"A Comparative Trial of Valacyclovir Hydrochloride ( 256U87 ) and Acyclovir for the Suppression of Anogenital Herpes Infections in HIV-Infected Patients", "orgStudyIdInfo"=>{"id"=>"104B"}, "secondaryIdInfos"=>[{"id"=>"07"}]}, "armsInterventionsModule"=>{"interventions"=>[{"name"=>"Valacyclovir hydrochloride", "type"=>"DRUG"}, {"name"=>"Acyclovir", "type"=>"DRUG"}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"36604", "city"=>"Mobile", "state"=>"Alabama", "country"=>"United States", "facility"=>"Univ of South Alabama", "geoPoint"=>{"lat"=>30.69436, "lon"=>-88.04305}}, {"zip"=>"85724", "city"=>"Tucson", "state"=>"Arizona", "country"=>"United States", "facility"=>"Univ of Arizona / Health Science Ctr", "geoPoint"=>{"lat"=>32.22174, "lon"=>-110.92648}}, {"zip"=>"90028", "city"=>"Los Angeles", "state"=>"California", "country"=>"United States", "facility"=>"Combat Group", "geoPoint"=>{"lat"=>34.05223, "lon"=>-118.24368}}, {"zip"=>"90033", "city"=>"Los Angeles", "state"=>"California", "country"=>"United States", "facility"=>"Los Angeles County - USC Med Ctr", "geoPoint"=>{"lat"=>34.05223, "lon"=>-118.24368}}, {"zip"=>"94609", "city"=>"Oakland", "state"=>"California", "country"=>"United States", "facility"=>"Infectious Disease Med Group / Adult Immunology Clinic", "geoPoint"=>{"lat"=>37.80437, "lon"=>-122.2708}}, {"zip"=>"92668", "city"=>"Orange", "state"=>"California", "country"=>"United States", "facility"=>"UCI Med Ctr", "geoPoint"=>{"lat"=>33.78779, "lon"=>-117.85311}}, {"zip"=>"92103", "city"=>"San Diego", "state"=>"California", "country"=>"United States", "facility"=>"UCSD Med Ctr", "geoPoint"=>{"lat"=>32.71533, "lon"=>-117.15726}}, {"zip"=>"921345000", "city"=>"San Diego", "state"=>"California", "country"=>"United States", "facility"=>"San Diego Naval Hosp", "geoPoint"=>{"lat"=>32.71533, "lon"=>-117.15726}}, {"zip"=>"94103", "city"=>"San Francisco", "state"=>"California", "country"=>"United States", "facility"=>"ViRx Inc", "geoPoint"=>{"lat"=>37.77493, "lon"=>-122.41942}}, {"zip"=>"94110", "city"=>"San Francisco", "state"=>"California", "country"=>"United States", "facility"=>"UCSF - San Francisco Gen Hosp", "geoPoint"=>{"lat"=>37.77493, "lon"=>-122.41942}}, {"zip"=>"94115", "city"=>"San Francisco", "state"=>"California", "country"=>"United States", "facility"=>"Dr Marcus Conant", "geoPoint"=>{"lat"=>37.77493, "lon"=>-122.41942}}, {"zip"=>"06516", "city"=>"West Haven", "state"=>"Connecticut", "country"=>"United States", "facility"=>"West Haven Veterans Administration Med Ctr", "geoPoint"=>{"lat"=>41.27065, "lon"=>-72.94705}}, {"zip"=>"20007", "city"=>"Washington", "state"=>"District of Columbia", "country"=>"United States", "facility"=>"Georgetown Univ Med Ctr", "geoPoint"=>{"lat"=>38.89511, "lon"=>-77.03637}}, {"zip"=>"20009", "city"=>"Washington", "state"=>"District of Columbia", "country"=>"United States", "facility"=>"Whitman - Walker Clinic", "geoPoint"=>{"lat"=>38.89511, "lon"=>-77.03637}}, {"zip"=>"20037", "city"=>"Washington", "state"=>"District of Columbia", "country"=>"United States", "facility"=>"George Washington Univ Med Ctr", "geoPoint"=>{"lat"=>38.89511, "lon"=>-77.03637}}, {"zip"=>"20422", "city"=>"Washington", "state"=>"District of Columbia", "country"=>"United States", "facility"=>"Veterans Administration Med Ctr / Regional AIDS Program", "geoPoint"=>{"lat"=>38.89511, "lon"=>-77.03637}}, {"zip"=>"33705", "city"=>"St. Petersburg", "state"=>"Florida", "country"=>"United States", "facility"=>"Univ of South Florida", "geoPoint"=>{"lat"=>27.77086, "lon"=>-82.67927}}, {"zip"=>"30303", "city"=>"Atlanta", "state"=>"Georgia", "country"=>"United States", "facility"=>"Emory Univ School of Medicine", "geoPoint"=>{"lat"=>33.749, "lon"=>-84.38798}}, {"zip"=>"30308", "city"=>"Atlanta", "state"=>"Georgia", "country"=>"United States", "facility"=>"AIDS Research Consortium of Atlanta", "geoPoint"=>{"lat"=>33.749, "lon"=>-84.38798}}, {"zip"=>"60611", "city"=>"Chicago", "state"=>"Illinois", "country"=>"United States", "facility"=>"Northwestern Memorial Hosp", "geoPoint"=>{"lat"=>41.85003, "lon"=>-87.65005}}, {"zip"=>"60612", "city"=>"Chicago", "state"=>"Illinois", "country"=>"United States", "facility"=>"Rush Presbyterian - Saint Luke's Med Ctr", "geoPoint"=>{"lat"=>41.85003, "lon"=>-87.65005}}, {"zip"=>"46202", "city"=>"Indianapolis", "state"=>"Indiana", "country"=>"United States", "facility"=>"Infectious Diseases Research Clinic / Indiana Univ Hosp", "geoPoint"=>{"lat"=>39.76838, "lon"=>-86.15804}}, {"zip"=>"52242", "city"=>"Iowa City", "state"=>"Iowa", "country"=>"United States", "facility"=>"Univ of Iowa Hosp & Clinic", "geoPoint"=>{"lat"=>41.66113, "lon"=>-91.53017}}, {"zip"=>"67214", "city"=>"Wichita", "state"=>"Kansas", "country"=>"United States", "facility"=>"Univ of Kansas School of Medicine", "geoPoint"=>{"lat"=>37.69224, "lon"=>-97.33754}}, {"zip"=>"21201", "city"=>"Baltimore", "state"=>"Maryland", "country"=>"United States", "facility"=>"Univ of Maryland at Baltimore", "geoPoint"=>{"lat"=>39.29038, "lon"=>-76.61219}}, {"zip"=>"55101", "city"=>"St. Paul", "state"=>"Minnesota", "country"=>"United States", "facility"=>"St Paul Ramsey Med Ctr", "geoPoint"=>{"lat"=>44.94441, "lon"=>-93.09327}}, {"zip"=>"39216", "city"=>"Jackson", "state"=>"Mississippi", "country"=>"United States", "facility"=>"Univ of Mississippi Med Ctr", "geoPoint"=>{"lat"=>32.29876, "lon"=>-90.18481}}, {"zip"=>"64108", "city"=>"Kansas City", "state"=>"Missouri", "country"=>"United States", "facility"=>"Univ of Missouri at Kansas City School of Medicine", "geoPoint"=>{"lat"=>39.09973, 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Veterans Adm Med Ctr / Rsch & Education Grp", "geoPoint"=>{"lat"=>45.52345, "lon"=>-122.67621}}, {"zip"=>"19107", "city"=>"Philadelphia", "state"=>"Pennsylvania", "country"=>"United States", "facility"=>"Buckley Braffman Stern Med Associates", "geoPoint"=>{"lat"=>39.95233, "lon"=>-75.16379}}, {"zip"=>"15261", "city"=>"Pittsburgh", "state"=>"Pennsylvania", "country"=>"United States", "facility"=>"Univ of Pittsburgh / Graduate School of Public Health", "geoPoint"=>{"lat"=>40.44062, "lon"=>-79.99589}}, {"zip"=>"02908", "city"=>"Providence", "state"=>"Rhode Island", "country"=>"United States", "facility"=>"Roger Williams Med Ctr", "geoPoint"=>{"lat"=>41.82399, "lon"=>-71.41283}}, {"zip"=>"38103", "city"=>"Memphis", "state"=>"Tennessee", "country"=>"United States", "facility"=>"Regional Med Ctr at Memphis", "geoPoint"=>{"lat"=>35.14953, "lon"=>-90.04898}}, {"zip"=>"75246", "city"=>"Dallas", "state"=>"Texas", "country"=>"United States", "facility"=>"Dallas Associated Dermatologists", 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"country"=>"United States", "facility"=>"Univ TX Med Branch / Ctr for Clinical Studies", "geoPoint"=>{"lat"=>29.54468, "lon"=>-95.09104}}, {"zip"=>"232980049", "city"=>"Richmond", "state"=>"Virginia", "country"=>"United States", "facility"=>"Med College of Virginia", "geoPoint"=>{"lat"=>37.55376, "lon"=>-77.46026}}]}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"Glaxo Wellcome", "class"=>"INDUSTRY"}}}}
