A Multiple Dose Crossover Pharmacokinetics Study to Evaluate the Effects of Food on the Absorption of Oral Ganciclovir
Launched by HOFFMANN-LA ROCHE · Aug 30, 2001
Trial Information
Current as of July 02, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- Patients must have the following:
- • Confirmation of HIV infection by HIV antibody testing, p24 antigen, or culture of HIV.
- • Documented confirmation of present or past CMV infection.
- • Must understand the nature of the study, agree to tests required in the protocol, and must understand and sign an informed Consent form approved by the appropriate Institutional Review Board and by Syntex.
- • Exclusion Criteria
- Co-existing Condition:
- Patients with the following conditions or symptoms are excluded:
- • Uncontrolled diarrhea or clinically significant gastrointestinal symptoms including persistent nausea or abdominal pain.
- Concurrent Medication:
- Excluded:
- • Antimetabolites. Interferons. Other nucleoside analogs. Zidovudine (AZT). Any investigational drug.
- Patients with the following are excluded:
- • Any concomitant conditions listed in Exclusion Co-Existing Conditions.
- • Karnofsky score \< 70.
- • Hypersensitivity to acyclovir.
- • Displaying signs of dementia or decreased mentation which would interfere with the ability of the subject to follow protocol schedule.
- Prior Medication:
- Excluded:
- • Anti-cytomegalovirus therapy including ganciclovir therapy for treatment of CMV disease.
- * Excluded within 4 days of study entry:
- • Antimetabolites.
- • Interferons.
- • Other nucleoside analogs.
- • Zidovudine (AZT).
About Hoffmann La Roche
Hoffmann-La Roche, commonly known as Roche, is a global leader in biotechnology and pharmaceuticals, committed to advancing healthcare through innovative research and development. With a strong focus on oncology, immunology, infectious diseases, and central nervous system disorders, Roche leverages cutting-edge science to deliver transformative therapies and diagnostics. The company is dedicated to improving patient outcomes by conducting rigorous clinical trials and collaborating with healthcare professionals and organizations worldwide. Roche's unwavering commitment to precision medicine and personalized healthcare positions it at the forefront of the industry, driving progress in the quest for effective treatments and improved patient care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Washington, District Of Columbia, United States
San Francisco, California, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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