Search / Trial NCT00002402

A Study of AIDSVAX B/B and AIDSVAX B/E, Two Possible Vaccines

Launched by VAXGEN · Aug 30, 2001

Trial Information

Current as of November 03, 2024

Completed

Keywords

Hiv 1 Dose Response Relationship, Drug Acquired Immunodeficiency Syndrome Aids Vaccines Hiv Seronegativity Antigens, Viral Alum Compounds

ClinConnect Summary

Patients are randomized to 1 of the 2 following arms and administered 1 or 2 injections into the deltoid muscle at 0, 1, 6, and 12 months:

Arm A: Patients receive 1 of 3 doses of AIDSVAX B/B vaccine (MN rgp120/HIV-1 plus GNE8 rgp120/HIV-1) in alum adjuvant.

Arm B: Patients receive AIDSVAX B/E (MN rgp120/HIV-1 plus A244 rgp120/HIV-1) vaccine in alum adjuvant.

Patients are evaluated at 1 hr, 3 days, and 14 days after each immunization and at 18 months after the first immunization.

An interim analysis is performed after all patients receive the second dose (at 1 month).

Gender

ALL

Eligibility criteria

  • Patients must:
  • Be HIV-uninfected men and women at low or intermediate risk for HIV-1 infection.

About Vaxgen

Vaxgen is a biopharmaceutical company focused on the development and commercialization of innovative vaccines to combat infectious diseases and improve public health outcomes. With a commitment to scientific excellence and patient safety, Vaxgen conducts rigorous clinical trials to evaluate the efficacy and safety of its vaccine candidates. The company leverages advanced technologies and collaborative partnerships to drive research and development, aiming to address unmet medical needs and enhance global vaccination efforts. Through its dedication to innovation and quality, Vaxgen strives to contribute significantly to the field of immunization and disease prevention.

Locations

Boston, Massachusetts, United States

Denver, Colorado, United States

Washington, District Of Columbia, United States

Saint Louis, Missouri, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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