Nctid:
NCT00002552
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-12-06"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D008223", "term"=>"Lymphoma"}, {"id"=>"D009101", "term"=>"Multiple Myeloma"}, {"id"=>"D054219", "term"=>"Neoplasms, Plasma Cell"}, {"id"=>"D008228", "term"=>"Lymphoma, Non-Hodgkin"}, {"id"=>"D006689", "term"=>"Hodgkin Disease"}, {"id"=>"D010954", "term"=>"Plasmacytoma"}], "ancestors"=>[{"id"=>"D009370", "term"=>"Neoplasms by Histologic Type"}, {"id"=>"D009369", "term"=>"Neoplasms"}, {"id"=>"D008232", "term"=>"Lymphoproliferative Disorders"}, {"id"=>"D008206", "term"=>"Lymphatic Diseases"}, {"id"=>"D007160", "term"=>"Immunoproliferative Disorders"}, {"id"=>"D007154", "term"=>"Immune System Diseases"}, {"id"=>"D020141", "term"=>"Hemostatic Disorders"}, {"id"=>"D014652", "term"=>"Vascular Diseases"}, {"id"=>"D002318", "term"=>"Cardiovascular Diseases"}, {"id"=>"D010265", "term"=>"Paraproteinemias"}, {"id"=>"D001796", "term"=>"Blood Protein Disorders"}, {"id"=>"D006402", "term"=>"Hematologic Diseases"}, {"id"=>"D006474", "term"=>"Hemorrhagic Disorders"}], "browseLeaves"=>[{"id"=>"M11220", "name"=>"Lymphoma", "asFound"=>"Lymphoma", "relevance"=>"HIGH"}, {"id"=>"M11222", "name"=>"Lymphoma, Non-Hodgkin", "asFound"=>"Non-Hodgkin Lymphoma", "relevance"=>"HIGH"}, {"id"=>"M27585", "name"=>"Precursor Cell Lymphoblastic Leukemia-Lymphoma", "relevance"=>"LOW"}, {"id"=>"M18828", "name"=>"Lymphoma, B-Cell", "relevance"=>"LOW"}, {"id"=>"M14850", "name"=>"Recurrence", "relevance"=>"LOW"}, {"id"=>"M12058", "name"=>"Multiple Myeloma", "asFound"=>"Multiple Myeloma", "relevance"=>"HIGH"}, {"id"=>"M27588", "name"=>"Neoplasms, Plasma Cell", "asFound"=>"Multiple Myeloma", "relevance"=>"HIGH"}, {"id"=>"M18831", "name"=>"Lymphoma, Large B-Cell, Diffuse", "relevance"=>"LOW"}, {"id"=>"M13844", "name"=>"Plasmacytoma", "asFound"=>"Plasma Cell Neoplasm", "relevance"=>"HIGH"}, {"id"=>"M11221", "name"=>"Lymphoma, Follicular", "relevance"=>"LOW"}, {"id"=>"M18116", "name"=>"Leukemia, Lymphocytic, Chronic, B-Cell", "relevance"=>"LOW"}, {"id"=>"M20554", "name"=>"Lymphoma, B-Cell, Marginal Zone", "relevance"=>"LOW"}, {"id"=>"M5321", "name"=>"Burkitt Lymphoma", "relevance"=>"LOW"}, {"id"=>"M9751", "name"=>"Hodgkin Disease", "asFound"=>"Hodgkin's Disease", "relevance"=>"HIGH"}, {"id"=>"M22307", "name"=>"Lymphoma, Mantle-Cell", "relevance"=>"LOW"}, {"id"=>"M381", "name"=>"Plasmablastic Lymphoma", "relevance"=>"LOW"}, {"id"=>"M18830", "name"=>"Lymphoma, Large-Cell, Immunoblastic", "relevance"=>"LOW"}, {"id"=>"M12315", "name"=>"Neoplasms by Histologic Type", "relevance"=>"LOW"}, {"id"=>"M11225", "name"=>"Lymphoproliferative Disorders", "relevance"=>"LOW"}, {"id"=>"M11203", "name"=>"Lymphatic Diseases", "relevance"=>"LOW"}, {"id"=>"M10206", "name"=>"Immunoproliferative Disorders", "relevance"=>"LOW"}, {"id"=>"M10200", "name"=>"Immune System Diseases", "relevance"=>"LOW"}, {"id"=>"M21977", "name"=>"Hemostatic Disorders", "relevance"=>"LOW"}, {"id"=>"M5059", "name"=>"Blood Coagulation Disorders", "relevance"=>"LOW"}, {"id"=>"M17400", "name"=>"Vascular Diseases", "relevance"=>"LOW"}, {"id"=>"M13178", "name"=>"Paraproteinemias", "relevance"=>"LOW"}, {"id"=>"M5077", "name"=>"Blood Protein Disorders", "relevance"=>"LOW"}, {"id"=>"M9490", "name"=>"Hematologic Diseases", "relevance"=>"LOW"}, {"id"=>"M9560", "name"=>"Hemorrhagic Disorders", "relevance"=>"LOW"}, {"id"=>"T175", "name"=>"Acute Lymphoblastic Leukemia", "relevance"=>"LOW"}, {"id"=>"T640", "name"=>"B-cell Lymphoma", "relevance"=>"LOW"}, {"id"=>"T3543", "name"=>"Lymphosarcoma", "asFound"=>"Lymphoma", "relevance"=>"HIGH"}, {"id"=>"T3947", "name"=>"Multiple Myeloma", "asFound"=>"Multiple Myeloma", "relevance"=>"HIGH"}, {"id"=>"T3533", "name"=>"Lymphoblastic Lymphoma", "relevance"=>"LOW"}, {"id"=>"T1866", "name"=>"Diffuse Large B-Cell Lymphoma", "relevance"=>"LOW"}, {"id"=>"T4587", "name"=>"Plasmacytoma", "asFound"=>"Plasma Cell Neoplasm", "relevance"=>"HIGH"}, {"id"=>"T2361", "name"=>"Follicular Lymphoma", "relevance"=>"LOW"}, {"id"=>"T1308", "name"=>"Chronic Lymphocytic Leukemia", "relevance"=>"LOW"}, {"id"=>"T3612", "name"=>"Marginal Zone Lymphoma", "relevance"=>"LOW"}, {"id"=>"T892", "name"=>"Burkitt Lymphoma", "relevance"=>"LOW"}, {"id"=>"T3601", "name"=>"Mantle Cell Lymphoma", "relevance"=>"LOW"}, {"id"=>"T2817", "name"=>"Hodgkin Lymphoma", "relevance"=>"LOW"}, {"id"=>"T4586", "name"=>"Plasmablastic Lymphoma", "relevance"=>"LOW"}, {"id"=>"T3539", "name"=>"Lymphoma, Large-cell, Immunoblastic", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Neoplasms", "abbrev"=>"BC04"}, {"name"=>"Blood and Lymph Conditions", "abbrev"=>"BC15"}, {"name"=>"Immune System Diseases", "abbrev"=>"BC20"}, {"name"=>"All Conditions", "abbrev"=>"All"}, {"name"=>"Symptoms and General Pathology", "abbrev"=>"BC23"}, {"name"=>"Heart and Blood Diseases", "abbrev"=>"BC14"}, {"name"=>"Infections", "abbrev"=>"BC01"}, {"name"=>"Rare Diseases", "abbrev"=>"Rare"}]}, "interventionBrowseModule"=>{"meshes"=>[{"id"=>"D002955", "term"=>"Leucovorin"}, {"id"=>"D003561", "term"=>"Cytarabine"}, {"id"=>"D006854", "term"=>"Hydrocortisone"}, {"id"=>"C033014", "term"=>"Hydrocortisone 17-butyrate 21-propionate"}, {"id"=>"C021650", "term"=>"Hydrocortisone acetate"}, {"id"=>"C007133", "term"=>"Hydrocortisone hemisuccinate"}, {"id"=>"D003520", "term"=>"Cyclophosphamide"}, {"id"=>"D002330", "term"=>"Carmustine"}, {"id"=>"D008727", "term"=>"Methotrexate"}, {"id"=>"D005047", "term"=>"Etoposide"}, {"id"=>"C081222", "term"=>"Sargramostim"}, {"id"=>"D058766", "term"=>"Levoleucovorin"}], "ancestors"=>[{"id"=>"D007166", "term"=>"Immunosuppressive Agents"}, {"id"=>"D007155", "term"=>"Immunologic Factors"}, {"id"=>"D045505", "term"=>"Physiological Effects of Drugs"}, {"id"=>"D018501", "term"=>"Antirheumatic Agents"}, {"id"=>"D018906", "term"=>"Antineoplastic Agents, Alkylating"}, {"id"=>"D000477", "term"=>"Alkylating Agents"}, {"id"=>"D045504", "term"=>"Molecular Mechanisms of Pharmacological Action"}, {"id"=>"D000970", "term"=>"Antineoplastic Agents"}, {"id"=>"D019653", "term"=>"Myeloablative Agonists"}, {"id"=>"D000020", "term"=>"Abortifacient Agents, Nonsteroidal"}, {"id"=>"D000019", "term"=>"Abortifacient Agents"}, {"id"=>"D012102", "term"=>"Reproductive Control Agents"}, {"id"=>"D000964", "term"=>"Antimetabolites, Antineoplastic"}, {"id"=>"D000963", "term"=>"Antimetabolites"}, {"id"=>"D003879", "term"=>"Dermatologic Agents"}, {"id"=>"D004791", "term"=>"Enzyme Inhibitors"}, {"id"=>"D005493", "term"=>"Folic Acid Antagonists"}, {"id"=>"D019384", "term"=>"Nucleic Acid Synthesis Inhibitors"}, {"id"=>"D000972", "term"=>"Antineoplastic Agents, Phytogenic"}, {"id"=>"D059005", "term"=>"Topoisomerase II Inhibitors"}, {"id"=>"D059003", "term"=>"Topoisomerase Inhibitors"}, {"id"=>"D000998", "term"=>"Antiviral Agents"}, {"id"=>"D000890", "term"=>"Anti-Infective Agents"}, {"id"=>"D000931", "term"=>"Antidotes"}, {"id"=>"D020011", "term"=>"Protective Agents"}, {"id"=>"D014803", "term"=>"Vitamin B Complex"}, {"id"=>"D014815", "term"=>"Vitamins"}, {"id"=>"D018977", "term"=>"Micronutrients"}, {"id"=>"D000893", "term"=>"Anti-Inflammatory Agents"}], "browseLeaves"=>[{"id"=>"M6727", "name"=>"Cyclophosphamide", "asFound"=>"Tablet", "relevance"=>"HIGH"}, {"id"=>"M8191", "name"=>"Etoposide", "asFound"=>"Different", "relevance"=>"HIGH"}, {"id"=>"M11703", "name"=>"Methotrexate", "asFound"=>"Surgical", "relevance"=>"HIGH"}, {"id"=>"M6191", "name"=>"Leucovorin", "asFound"=>"May", "relevance"=>"HIGH"}, {"id"=>"M1945", "name"=>"Lenograstim", "relevance"=>"LOW"}, {"id"=>"M5381", "name"=>"Calcium", "relevance"=>"LOW"}, {"id"=>"M5398", "name"=>"Calcium, Dietary", "relevance"=>"LOW"}, {"id"=>"M29233", "name"=>"Levoleucovorin", "asFound"=>"Cognitive Behavioral Therapy", "relevance"=>"HIGH"}, {"id"=>"M341643", "name"=>"Etoposide phosphate", "relevance"=>"LOW"}, {"id"=>"M6766", "name"=>"Cytarabine", "asFound"=>"PET", "relevance"=>"HIGH"}, {"id"=>"M5585", "name"=>"Carmustine", "asFound"=>"Chamber", "relevance"=>"HIGH"}, {"id"=>"M257633", "name"=>"Molgramostim", "relevance"=>"LOW"}, {"id"=>"M219218", "name"=>"Sargramostim", "asFound"=>"Pancreatic Cancer", "relevance"=>"HIGH"}, {"id"=>"M9912", "name"=>"Hydrocortisone", "asFound"=>"Monoclonal", "relevance"=>"HIGH"}, {"id"=>"M155245", "name"=>"Hydrocortisone 17-butyrate 21-propionate", "asFound"=>"Vaccinia", "relevance"=>"HIGH"}, {"id"=>"M228609", "name"=>"Hydrocortisone acetate", "asFound"=>"Vaccinia", "relevance"=>"HIGH"}, {"id"=>"M263259", "name"=>"Hydrocortisone hemisuccinate", "asFound"=>"Vaccinia", "relevance"=>"HIGH"}, {"id"=>"M242077", "name"=>"Hydrocortisone-17-butyrate", "relevance"=>"LOW"}, {"id"=>"M10212", "name"=>"Immunosuppressive Agents", "relevance"=>"LOW"}, {"id"=>"M10201", "name"=>"Immunologic Factors", "relevance"=>"LOW"}, {"id"=>"M20604", "name"=>"Antirheumatic Agents", "relevance"=>"LOW"}, {"id"=>"M20942", "name"=>"Antineoplastic Agents, Alkylating", "relevance"=>"LOW"}, {"id"=>"M3820", "name"=>"Alkylating Agents", "relevance"=>"LOW"}, {"id"=>"M4281", "name"=>"Antimetabolites", "relevance"=>"LOW"}, {"id"=>"M7074", "name"=>"Dermatologic Agents", "relevance"=>"LOW"}, {"id"=>"M7951", "name"=>"Enzyme Inhibitors", "relevance"=>"LOW"}, {"id"=>"M17546", "name"=>"Vitamin B Complex", "relevance"=>"LOW"}, {"id"=>"M8618", "name"=>"Folic Acid", "relevance"=>"LOW"}, {"id"=>"M8619", "name"=>"Folic Acid Antagonists", "relevance"=>"LOW"}, {"id"=>"M4314", "name"=>"Antiviral Agents", "relevance"=>"LOW"}, {"id"=>"M4214", "name"=>"Anti-Infective Agents", "relevance"=>"LOW"}, {"id"=>"M4250", "name"=>"Antidotes", "relevance"=>"LOW"}, {"id"=>"M21869", "name"=>"Protective Agents", "relevance"=>"LOW"}, {"id"=>"M17558", "name"=>"Vitamins", "relevance"=>"LOW"}, {"id"=>"M21009", "name"=>"Micronutrients", "relevance"=>"LOW"}, {"id"=>"M16885", "name"=>"Trace Elements", "relevance"=>"LOW"}, {"id"=>"M4217", "name"=>"Anti-Inflammatory Agents", "relevance"=>"LOW"}, {"id"=>"T447", "name"=>"Folinic Acid", "asFound"=>"Cognitive Behavioral Therapy", "relevance"=>"HIGH"}, {"id"=>"T446", "name"=>"Folic Acid", "relevance"=>"LOW"}, {"id"=>"T448", "name"=>"Folate", "relevance"=>"LOW"}, {"id"=>"T475", "name"=>"Vitamin B9", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Antineoplastic Agents", "abbrev"=>"ANeo"}, {"name"=>"Antirheumatic Agents", "abbrev"=>"ARhu"}, {"name"=>"All Drugs and Chemicals", "abbrev"=>"All"}, {"name"=>"Dermatologic Agents", "abbrev"=>"Derm"}, {"name"=>"Reproductive Control Agents", "abbrev"=>"Repr"}, {"name"=>"Micronutrients", "abbrev"=>"Micro"}, {"name"=>"Bone Density Conservation Agents", "abbrev"=>"BDCA"}, {"name"=>"Anti-Infective Agents", "abbrev"=>"Infe"}, {"name"=>"Anti-Inflammatory Agents", "abbrev"=>"Infl"}, {"name"=>"Hematinics", "abbrev"=>"Hemat"}, {"name"=>"Vitamins", "abbrev"=>"Vi"}]}}, "protocolSection"=>{"designModule"=>{"phases"=>["PHASE2"], "studyType"=>"INTERVENTIONAL", "designInfo"=>{"primaryPurpose"=>"TREATMENT"}, "enrollmentInfo"=>{"type"=>"ESTIMATED", "count"=>40}}, "statusModule"=>{"overallStatus"=>"COMPLETED", "startDateStruct"=>{"date"=>"1993-10"}, "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2013-04", "completionDateStruct"=>{"date"=>"2003-10", "type"=>"ACTUAL"}, "lastUpdateSubmitDate"=>"2013-04-05", "studyFirstSubmitDate"=>"1999-11-01", "studyFirstSubmitQcDate"=>"2004-05-21", "lastUpdatePostDateStruct"=>{"date"=>"2013-04-09", "type"=>"ESTIMATED"}, "studyFirstPostDateStruct"=>{"date"=>"2004-05-24", "type"=>"ESTIMATED"}, "primaryCompletionDateStruct"=>{"date"=>"2001-09", "type"=>"ACTUAL"}}, "oversightModule"=>{"oversightHasDmc"=>true}, "conditionsModule"=>{"keywords"=>["recurrent adult Hodgkin lymphoma", "refractory multiple myeloma", "recurrent small lymphocytic lymphoma", "recurrent grade 1 follicular lymphoma", "recurrent grade 2 follicular lymphoma", "recurrent grade 3 follicular lymphoma", "recurrent adult diffuse small cleaved cell lymphoma", "recurrent adult diffuse mixed cell lymphoma", "recurrent adult diffuse large cell lymphoma", "recurrent adult immunoblastic large cell lymphoma", "recurrent adult lymphoblastic lymphoma", "recurrent adult Burkitt lymphoma", "recurrent mantle cell lymphoma", "recurrent marginal zone lymphoma", "extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue", "nodal marginal zone B-cell lymphoma", "splenic marginal zone lymphoma", "adult unfavorable prognosis Hodgkin lymphoma", "childhood unfavorable prognosis Hodgkin lymphoma"], "conditions"=>["Lymphoma", "Multiple Myeloma and Plasma Cell Neoplasm"]}, "descriptionModule"=>{"briefSummary"=>"RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining bone marrow transplantation with chemotherapy may allow doctors to give higher doses of chemotherapy and kill more tumor cells.\n\nPURPOSE: This phase II trial is studying the side effects of giving a bone marrow transplant together with chemotherapy and to see how well it works in treating patients with refractory non-Hodgkin's lymphoma, Hodgkin's lymphoma, or multiple myeloma.", "detailedDescription"=>"OBJECTIVES: I. Assess the toxicities, response rate, and duration of response associated with high-dose cyclophosphamide, etoposide, carmustine or high-dose cyclophosphamide and total-body irradiation followed by autologous, allogeneic, or syngeneic bone marrow transplant in patients with refractory or high-risk non-Hodgkin's lymphoma, Hodgkin's disease, or multiple myeloma. II. Evaluate any prognostic factors.\n\nOUTLINE: Patients with prior radiotherapy (greater than 2,000 cGy) receive cyclophosphamide IV over 2 hours and etoposide IV over at least 30 minutes on days -7 through -4 followed by carmustine IV over 2 hours on day -3. Patients receive allogeneic or autologous bone marrow transplantation on day 0. Patients with or without prior radiotherapy (less than 2,000 cGy) receive cyclophosphamide IV over 2 hours on days -8 through -5 followed by total body irradiation on days -4 through -1. Patients receive allogeneic or autologous bone marrow transplantation on day 0. Prior to autologous bone marrow transplantation and following myeloablative chemotherapy, patients undergo mobilization consisting of cytarabine subcutaneously every 12 hours for 6 doses. Approximately 24 hours later, patients receive sargramostim (GM-CSF) subcutaneously. Peripheral blood stem cells are collected every 1-3 days beginning when blood counts recover and continuing until sufficient number of cells are reached.\n\nPROJECTED ACCRUAL: Approximately 40 patients will be accrued for this study."}, "eligibilityModule"=>{"sex"=>"ALL", "stdAges"=>["CHILD", "ADULT", "OLDER_ADULT"], "maximumAge"=>"70 years", "healthyVolunteers"=>false, "eligibilityCriteria"=>"DISEASE CHARACTERISTICS: Histologically proven Hodgkin's disease (HD), non-Hodgkin's lymphoma (NHL), and multiple myeloma (MM) meeting the following requirements: Refractory to or at high risk following prior therapy Responded with at least a partial response to last cytoreductive regimen No bulky disease (individual tumor diameter larger than 5 cm) Eligible HD: CNS involvement at original presentation and currently in complete response (CR) Relapsed within 1 year following completion of front-line MOPP or ABVD Relapsed at any time following front-line MOPP/ABVD or other hybrid Eligible NHL: Any grade lymphoma with CNS involvement at original presentation and currently in CR High-grade lymphomas (International Working Formulation H-J) with marrow involvement at original presentation and currently in CR, EXCEPT: Immunoblastic lymphoma and large cell (IWF G and H) with bone marrow involvement with small cleaved cell at original presentation High-/intermediate-grade lymphomas (IWF D-J) in relapse after adequate front-line therapy High-/intermediate-grade lymphomas (IWF D-J) that failed to achieve CR with adequate front-line therapy Low-grade lymphomas (IWF A-C) with B symptoms at original presentation and relapse after front-line therapy Low-grade lymphomas (IWF A-C) in relapse within 1 year following last chemotherapy Low-grade lymphomas (IWF A-C) with documented histologic conversion Eligible MM: Diagnosis based on either presence of both Group I diagnostic criteria OR One Group I criterion and all Group II criteria Group I diagnostic criteria: Plasma cells and/or myeloma cells greater than 10% in bone marrow Biopsy-proven plasmacytoma in bone or soft tissue Group II diagnostic criteria: Monoclonal serum protein spike Urinary myeloma protein Osteolytic lesions on radiologic examination Generalized osteoporosis suffices if plasma cells in marrow exceed 30% Myeloma cells in at least 2 peripheral blood smears Stage II/III disease documented sometime during clinical course Stage III defined by presence of at least 1 of the following: Hemoglobin less than 8.5 g/dl Serum calcium greater than 12 mg/dl Advanced lytic bone lesions High M-component production rates: IgG greater than 7 g/dl IgA greater than 5 g/dl Urinary light chain greater than 4 g/24 hours Stage II disease defined by absence of Stage III characteristics but presence of at least 1 of the following: Hb less than 10 g/dl More than 1 osteolytic lesion, none advanced IgG greater than 5 g/dl IgA greater than 3 g/dl Bone marrow donor available for lymphoma patients with marrow involvement Perfosfamide-purged autologous transplant allowed in patients with no matched sibling donor if: Marrow involvement is limited (less than 30% tumor cells on smears and in bilateral iliac crest biopsies) AND Age is under 60 Donor requirements: Excellent physical condition by history, lab studies, PE No physiologic, psychologic, or medical inability to tolerate the procedure No increased anesthetic risk No HIV infection Priority of multiple donors (in order given): ABO compatible Age over 18 Same sex as recipient A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of \"indolent\" or \"aggressive\" lymphoma will replace the former terminology of \"low\", \"intermediate\", or \"high\" grade lymphoma. However, this protocol uses the former terminology.\n\nPATIENT CHARACTERISTICS: Age: 70 and under Performance status: 0-2 Life expectancy: No severe limitation due to nonmalignant disease Hematopoietic: Not specified Hepatic: No severe hepatic disease Bilirubin no greater than 2.0 mg/dL Transaminases no greater than 3 times normal Renal: No severe renal disease Creatinine no greater than 1.5 mg/dL Creatinine clearance at least 60 mL/min Cardiovascular: No symptomatic cardiac disease LVEF at least 50% Pulmonary: No severe pulmonary disease FEV1 and FVC at least 75% of normal Other: No history of severe cystitis with cyclophosphamide No HIV infection No severe personality disorder or severe mental illness No other condition that would markedly increase the morbidity and mortality of transplantation (e.g., substance abuse) Patients with borderline parameters of organ function, performance status, or mental status are entered at the discretion of the transplant team\n\nPRIOR CONCURRENT THERAPY: See Disease Characteristics"}, "identificationModule"=>{"nctId"=>"NCT00002552", "briefTitle"=>"Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma", "organization"=>{"class"=>"OTHER", "fullName"=>"Barbara Ann Karmanos Cancer Institute"}, "officialTitle"=>"AUTOLOGOUS, ALLOGENEIC, OR SYNGENEIC BONE MARROW TRANSPLANTATION IN HODGKIN'S DISEASE, NON-HODGKIN'S LYMPHOMA, AND MULTIPLE MYELOMA", "orgStudyIdInfo"=>{"id"=>"CDR0000063370"}, "secondaryIdInfos"=>[{"id"=>"P30CA022453", "link"=>"https://reporter.nih.gov/quickSearch/P30CA022453", "type"=>"NIH"}, {"id"=>"WSU-D-701-87"}, {"id"=>"NCI-V94-0364"}]}, "armsInterventionsModule"=>{"interventions"=>[{"name"=>"filgrastim", "type"=>"BIOLOGICAL"}, {"name"=>"sargramostim", "type"=>"BIOLOGICAL"}, {"name"=>"carmustine", "type"=>"DRUG"}, {"name"=>"cyclophosphamide", "type"=>"DRUG"}, {"name"=>"cytarabine", "type"=>"DRUG"}, {"name"=>"etoposide", "type"=>"DRUG"}, {"name"=>"leucovorin calcium", "type"=>"DRUG"}, {"name"=>"methotrexate", "type"=>"DRUG"}, {"name"=>"perfosfamide", "type"=>"DRUG"}, {"name"=>"therapeutic hydrocortisone", "type"=>"DRUG"}, {"name"=>"allogeneic bone marrow transplantation", "type"=>"PROCEDURE"}, {"name"=>"autologous bone marrow transplantation", "type"=>"PROCEDURE"}, {"name"=>"in vitro-treated bone marrow transplantation", "type"=>"PROCEDURE"}, {"name"=>"peripheral blood stem cell transplantation", "type"=>"PROCEDURE"}, {"name"=>"syngeneic bone marrow transplantation", "type"=>"PROCEDURE"}, {"name"=>"radiation therapy", "type"=>"RADIATION"}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"48201", "city"=>"Detroit", "state"=>"Michigan", "country"=>"United States", "facility"=>"Barbara Ann Karmanos Cancer Institute", "geoPoint"=>{"lat"=>42.33143, "lon"=>-83.04575}}], "overallOfficials"=>[{"name"=>"Roger Dansey, MD", "role"=>"STUDY_CHAIR", "affiliation"=>"Barbara Ann Karmanos Cancer Institute"}]}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"Barbara Ann Karmanos Cancer Institute", "class"=>"OTHER"}, "collaborators"=>[{"name"=>"National Cancer Institute (NCI)", "class"=>"NIH"}], "responsibleParty"=>{"type"=>"SPONSOR"}}}}
