Search / Trial NCT00002595

Toremifene in Treating Patients With Desmoid Tumors

Launched by ADVOCATE LUTHERAN GENERAL HOSPITAL · Apr 21, 2004

Trial Information

Current as of November 03, 2024

Completed

Keywords

Desmoid Tumor

Description

OBJECTIVES: I. Determine the efficacy of toremifene in terms of tumor response rate and symptom relief in patients with desmoid tumors. II. Determine the safety of this regimen in these patients. III. Determine the quality of life of patients treated with this regimen. OUTLINE: Patients are stratified by gender. Patients receive oral toremifene daily until complete or maximal response in the absence of disease progression or unacceptable toxicity. Patients achieving maximal response undergo complete resection of all lesions, if feasible. Nonsurgical candidates with severe or life-threateni...

Gender

ALL

Eligibility criteria

  • DISEASE CHARACTERISTICS: Histologically proven primary or recurrent desmoid tumor Unresectable and symptomatic or progressive disease OR Disease for which a mutilating surgery would be required for complete resection Bidimensionally measurable or clinically evaluable disease
  • PATIENT CHARACTERISTICS: Age: 16 and over (no prepubertal patients) Performance status: 0-2 Life expectancy: More than 2 months Hematopoietic: Absolute granulocyte count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 2 mg/dL Transaminases no greater than 3 times upper limit of normal (ULN) Alkaline phosphatase no greater than 3 times ULN Renal: Not specified Cardiovascular: No history of deep vein thrombosis Other: Not pregnant Fertile patients must use effective barrier contraception
  • PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: No concurrent dexamethasone for antiemesis No other concurrent hormonal therapy, including hormonal contraceptives Radiotherapy: Not specified Surgery: See Disease Characteristics

About Advocate Lutheran General Hospital

Advocate Lutheran General Hospital is a leading healthcare institution committed to advancing medical research and improving patient care through innovative clinical trials. As part of the Advocate Aurora Health system, the hospital leverages its state-of-the-art facilities and a multidisciplinary team of healthcare professionals to conduct high-quality research across various therapeutic areas. With a focus on patient safety and ethical standards, Advocate Lutheran General Hospital aims to contribute significantly to the development of new treatments and therapies, enhancing health outcomes for the communities it serves.

Locations

Park Ridge, Illinois, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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