Radiation Therapy in Treating Patients With Stage II Cancer of the Vocal Cord
Launched by RADIATION THERAPY ONCOLOGY GROUP · Jan 26, 2003
Trial Information
Current as of August 19, 2025
Completed
Keywords
ClinConnect Summary
OBJECTIVES:
* Compare the local response rate in patients with stage II invasive squamous cell carcinoma of the true vocal cord treated with hyperfractionation vs conventional fractionation radiotherapy.
* Compare the acute and late toxic effects of these regimens in this patient population.
* Compare the overall and disease-free survival patterns in this patient population treated with these regimens.
OUTLINE: This is a randomized study. Patients are stratified according to substage (T2a vs T2b). Patients are randomized to 1 of 2 treatment arms.
* Arm I: Patients undergo conventional ra...
Gender
ALL
Eligibility criteria
- DISEASE CHARACTERISTICS:
- • Histologically proven invasive squamous cell carcinoma of the true vocal cord
- • Stage II (T2a/b N0) disease with bulk of tumor present on vocal cord (i.e., the epicenter) with extension to adjacent areas
- • No verrucal carcinoma or adenocarcinoma
- • No extension to pre-epiglottic space or pyriform sinus
- • No fixed cord or cartilage invasion
- * No evidence of adenopathy, including any of the following:
- • Nodes larger than 1 cm by radiography
- • Nodes containing a low central density consistent with necrosis by radiography
- • Clinically palpable nodes larger than 1 cm and firm in consistency
- • No recurrent or persistent disease
- • No evidence or suspicion of distant metastases
- PATIENT CHARACTERISTICS:
- Age:
- • 18 and over
- Performance status:
- • Karnofsky 60-100%
- Life expectancy:
- • Not specified
- Hematopoietic:
- • Not specified
- Hepatic:
- • Not specified
- Renal:
- • Not specified
- Other:
- • No other malignancy within the past 5 years except nonmelanomatous skin cancer
- • Not pregnant or nursing
- • Fertile patients must use effective contraception
- PRIOR CONCURRENT THERAPY:
- Biologic therapy:
- • Not specified
- Chemotherapy:
- • No prior chemotherapy
- Endocrine therapy:
- • Not specified
- Radiotherapy:
- • No prior radiotherapy to the mid-neck or larynx
- Surgery:
- • No prior complete stripping or laser excision of all gross disease
About Radiation Therapy Oncology Group
The Radiation Therapy Oncology Group (RTOG) is a leading clinical trial sponsor dedicated to advancing the field of radiation oncology through rigorous research and collaboration. Established to improve patient outcomes, RTOG conducts multicenter clinical trials that evaluate innovative radiation treatment techniques, assess the efficacy of combined modality therapies, and enhance quality of life for cancer patients. Committed to scientific excellence, RTOG fosters partnerships among academic institutions, healthcare providers, and industry stakeholders, ensuring that findings translate into clinical practice to optimize cancer care and improve survival rates.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Marshfield, Wisconsin, United States
Cleveland, Ohio, United States
Salt Lake City, Utah, United States
Akron, Ohio, United States
Buffalo, New York, United States
Calgary, Alberta, Canada
Fleurimont, Quebec, Canada
Houston, Texas, United States
Ann Arbor, Michigan, United States
Rochester, Minnesota, United States
Montreal, Quebec, Canada
Los Angeles, California, United States
Denver, Colorado, United States
Tampa, Florida, United States
Atlanta, Georgia, United States
Honolulu, Hawaii, United States
Lexington, Kentucky, United States
Detroit, Michigan, United States
Albany, New York, United States
Brooklyn, New York, United States
Chapel Hill, North Carolina, United States
Cleveland, Ohio, United States
Columbus, Ohio, United States
Hershey, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Spartanburg, South Carolina, United States
Milwaukee, Wisconsin, United States
Miami, Florida, United States
Flint, Michigan, United States
Greenville, North Carolina, United States
Burlington, Vermont, United States
Atlanta, Georgia, United States
Kansas City, Missouri, United States
Omaha, Nebraska, United States
Las Vegas, Nevada, United States
Miami Beach, Florida, United States
Baltimore, Maryland, United States
Columbia, Missouri, United States
Lebanon, New Hampshire, United States
Manhasset, New York, United States
Winston Salem, North Carolina, United States
Indianapolis, Indiana, United States
Kalamazoo, Michigan, United States
Saint Louis Park, Minnesota, United States
East Orange, New Jersey, United States
Pittsburgh, Pennsylvania, United States
Bloomington, Indiana, United States
Ann Arbor, Michigan, United States
Danville, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Nashville, Tennessee, United States
Milwaukee, Wisconsin, United States
Orlando, Florida, United States
Maywood, Illinois, United States
New Orleans, Louisiana, United States
Rapid City, South Dakota, United States
Birmingham, Alabama, United States
Winston Salem, North Carolina, United States
Charlottesville, Virginia, United States
Edmonton, , Canada
Regina, , Canada
Saskatoon, , Canada
Huntsville, Alabama, United States
Montgomery, Alabama, United States
Concord, California, United States
Fresno, California, United States
Fresno, California, United States
Loma Linda, California, United States
Long Beach, California, United States
Oakland, California, United States
Sacramento, California, United States
San Jose, California, United States
Santa Rosa, California, United States
Travis Air Force Base, California, United States
Colorado Springs, Colorado, United States
Gainesville, Florida, United States
Miami, Florida, United States
Panama City, Florida, United States
Sarasota, Florida, United States
Columbus, Georgia, United States
Arlington Heights, Illinois, United States
Chicago, Illinois, United States
Harvey, Illinois, United States
Park Ridge, Illinois, United States
Peoria, Illinois, United States
Anderson, Indiana, United States
Muncie, Indiana, United States
Dubuque, Iowa, United States
Louisville, Kentucky, United States
Louisville, Kentucky, United States
Madisonville, Kentucky, United States
Baton Rouge, Louisiana, United States
New Orleans, Louisiana, United States
Portland, Maine, United States
Annapolis, Maryland, United States
Baltimore, Maryland, United States
Baltimore, Maryland, United States
Hyannis, Massachusetts, United States
Jamaica Plain, Massachusetts, United States
Detroit, Michigan, United States
Flint, Michigan, United States
Marquette, Michigan, United States
Saint Louis, Missouri, United States
Saint Louis, Missouri, United States
Springfield, Missouri, United States
Springfield, Missouri, United States
Billings, Montana, United States
Manchester, New Hampshire, United States
Edison, New Jersey, United States
Newark, New Jersey, United States
Toms River, New Jersey, United States
Trenton, New Jersey, United States
Brooklyn, New York, United States
Plattsburgh, New York, United States
Concord, North Carolina, United States
Akron, Ohio, United States
Cincinnati, Ohio, United States
Columbus, Ohio, United States
Portland, Oregon, United States
Allentown, Pennsylvania, United States
Drexel Hill, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Reading, Pennsylvania, United States
Scranton, Pennsylvania, United States
Wilkes Barre, Pennsylvania, United States
Providence, Rhode Island, United States
Greenville, South Carolina, United States
Jackson, Tennessee, United States
Amarillo, Texas, United States
Galveston, Texas, United States
Lubbock, Texas, United States
Pasadena, Texas, United States
Saint George, Utah, United States
Portsmouth, Virginia, United States
Richmond, Virginia, United States
Seattle, Washington, United States
Spokane, Washington, United States
Yakima, Washington, United States
Green Bay, Wisconsin, United States
La Crosse, Wisconsin, United States
Madison, Wisconsin, United States
Madison, Wisconsin, United States
Menomonee Falls, Wisconsin, United States
Milwaukee, Wisconsin, United States
Milwaukee, Wisconsin, United States
Saint John, New Brunswick, Canada
Halifax, Nova Scotia, Canada
Hamilton, Ontario, Canada
Kingston, Ontario, Canada
London, Ontario, Canada
Sudbury, Ontario, Canada
Thunder Bay, Ontario, Canada
Toronto, Ontario, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Newark, Delaware, United States
Decatur, Illinois, United States
South Bend, Indiana, United States
Baltimore, Maryland, United States
Boston, Massachusetts, United States
Cleveland, Ohio, United States
Mobile, Alabama, United States
Los Angeles, California, United States
New Orleans, Louisiana, United States
New York, New York, United States
Syracuse, New York, United States
Tulsa, Oklahoma, United States
Quebec City, Quebec, Canada
Huntsville, Alabama, United States
Phoenix, Arizona, United States
Miami, Florida, United States
Panama City, Florida, United States
Tallahassee, Florida, United States
Salisbury, Maryland, United States
Midland, Michigan, United States
Royal Oak, Michigan, United States
Omaha, Nebraska, United States
Elizabeth, New Jersey, United States
Long Branch, New Jersey, United States
Millville, New Jersey, United States
New Brunswick, New Jersey, United States
Pomona, New Jersey, United States
Warren, New Jersey, United States
Oklahoma City, Oklahoma, United States
Tulsa, Oklahoma, United States
Salt Lake City, Utah, United States
Wheeling, West Virginia, United States
St. Johns, Newfoundland And Labrador, Canada
Baltimore, Maryland, United States
Rochester, New York, United States
Oklahoma City, Oklahoma, United States
Duarte, California, United States
San Francisco, California, United States
Dayton, Ohio, United States
Memphis, Tennessee, United States
Green Bay, Wisconsin, United States
Royal Oak, Michigan, United States
Denver, Colorado, United States
Ottawa, Ontario, Canada
Tuscaloosa, Alabama, United States
Greenbrae, California, United States
Pasadena, California, United States
Pomona, California, United States
San Diego, California, United States
Grand Junction, Colorado, United States
New Haven, Connecticut, United States
Jacksonville, Florida, United States
Melbourne, Florida, United States
Rome, Georgia, United States
Indianapolis, Indiana, United States
Indianapolis, Indiana, United States
Lexington, Kentucky, United States
Troy, Michigan, United States
Omaha, Nebraska, United States
Mount Holly, New Jersey, United States
Ridgewood, New Jersey, United States
Albuquerque, New Mexico, United States
Clifton Springs, New York, United States
Poughkeepsie, New York, United States
Yonkers, New York, United States
Minot, North Dakota, United States
Cincinnati, Ohio, United States
Toledo, Ohio, United States
Bethlehem, Pennsylvania, United States
Darby, Pennsylvania, United States
East Stroudsburg, Pennsylvania, United States
York, Pennsylvania, United States
Lackland Air Force Base, Texas, United States
Burlington, Vermont, United States
Harrisonburg, Virginia, United States
Richmond, Virginia, United States
Racine, Wisconsin, United States
Waukesha, Wisconsin, United States
Patients applied
Trial Officials
Andy M. Trotti, MD
Study Chair
H. Lee Moffitt Cancer Center and Research Institute
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials