Nctid:
NCT00002849
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-11-01"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D009101", "term"=>"Multiple Myeloma"}, {"id"=>"D000075363", "term"=>"Immunoglobulin Light-chain Amyloidosis"}, {"id"=>"D000686", "term"=>"Amyloidosis"}], "ancestors"=>[{"id"=>"D054219", "term"=>"Neoplasms, Plasma Cell"}, {"id"=>"D009370", "term"=>"Neoplasms by Histologic Type"}, {"id"=>"D009369", "term"=>"Neoplasms"}, {"id"=>"D020141", "term"=>"Hemostatic Disorders"}, {"id"=>"D014652", "term"=>"Vascular Diseases"}, {"id"=>"D002318", "term"=>"Cardiovascular Diseases"}, {"id"=>"D010265", "term"=>"Paraproteinemias"}, {"id"=>"D001796", "term"=>"Blood Protein Disorders"}, {"id"=>"D006402", "term"=>"Hematologic Diseases"}, {"id"=>"D006474", "term"=>"Hemorrhagic Disorders"}, {"id"=>"D008232", "term"=>"Lymphoproliferative Disorders"}, {"id"=>"D007160", "term"=>"Immunoproliferative Disorders"}, {"id"=>"D007154", "term"=>"Immune System Diseases"}, {"id"=>"D057165", "term"=>"Proteostasis Deficiencies"}, {"id"=>"D008659", "term"=>"Metabolic Diseases"}], "browseLeaves"=>[{"id"=>"M12058", "name"=>"Multiple Myeloma", "asFound"=>"Multiple Myeloma", "relevance"=>"HIGH"}, {"id"=>"M27588", "name"=>"Neoplasms, Plasma Cell", "relevance"=>"LOW"}, {"id"=>"M4021", "name"=>"Amyloidosis", "asFound"=>"Amyloidosis", "relevance"=>"HIGH"}, {"id"=>"M1483", "name"=>"Immunoglobulin Light-chain Amyloidosis", "asFound"=>"Primary systemic amyloidosis", "relevance"=>"HIGH"}, {"id"=>"M12315", "name"=>"Neoplasms by Histologic Type", "relevance"=>"LOW"}, {"id"=>"M21977", "name"=>"Hemostatic Disorders", "relevance"=>"LOW"}, {"id"=>"M5059", "name"=>"Blood Coagulation Disorders", "relevance"=>"LOW"}, {"id"=>"M17400", "name"=>"Vascular Diseases", "relevance"=>"LOW"}, {"id"=>"M13178", "name"=>"Paraproteinemias", "relevance"=>"LOW"}, {"id"=>"M5077", "name"=>"Blood Protein Disorders", "relevance"=>"LOW"}, {"id"=>"M9490", "name"=>"Hematologic Diseases", "relevance"=>"LOW"}, {"id"=>"M9560", "name"=>"Hemorrhagic Disorders", "relevance"=>"LOW"}, {"id"=>"M11225", "name"=>"Lymphoproliferative Disorders", "relevance"=>"LOW"}, {"id"=>"M10206", "name"=>"Immunoproliferative Disorders", "relevance"=>"LOW"}, {"id"=>"M10200", "name"=>"Immune System Diseases", "relevance"=>"LOW"}, {"id"=>"M28747", "name"=>"Proteostasis Deficiencies", "relevance"=>"LOW"}, {"id"=>"M11639", "name"=>"Metabolic Diseases", "relevance"=>"LOW"}, {"id"=>"T3947", "name"=>"Multiple Myeloma", "asFound"=>"Multiple Myeloma", "relevance"=>"HIGH"}, {"id"=>"T254", "name"=>"AL Amyloidosis", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Neoplasms", "abbrev"=>"BC04"}, {"name"=>"Heart and Blood Diseases", "abbrev"=>"BC14"}, {"name"=>"Blood and Lymph Conditions", "abbrev"=>"BC15"}, {"name"=>"Immune System Diseases", "abbrev"=>"BC20"}, {"name"=>"All Conditions", "abbrev"=>"All"}, {"name"=>"Nutritional and Metabolic Diseases", "abbrev"=>"BC18"}, {"name"=>"Rare Diseases", "abbrev"=>"Rare"}]}, "interventionBrowseModule"=>{"meshes"=>[{"id"=>"D007372", "term"=>"Interferons"}, {"id"=>"D016898", "term"=>"Interferon-alpha"}, {"id"=>"D003907", "term"=>"Dexamethasone"}], "ancestors"=>[{"id"=>"D000893", "term"=>"Anti-Inflammatory Agents"}, {"id"=>"D000932", "term"=>"Antiemetics"}, {"id"=>"D001337", "term"=>"Autonomic Agents"}, {"id"=>"D018373", "term"=>"Peripheral Nervous System Agents"}, {"id"=>"D045505", "term"=>"Physiological Effects of Drugs"}, {"id"=>"D005765", "term"=>"Gastrointestinal Agents"}, {"id"=>"D005938", "term"=>"Glucocorticoids"}, {"id"=>"D006728", "term"=>"Hormones"}, {"id"=>"D006730", "term"=>"Hormones, Hormone Substitutes, and Hormone Antagonists"}, {"id"=>"D018931", "term"=>"Antineoplastic Agents, Hormonal"}, {"id"=>"D000970", "term"=>"Antineoplastic Agents"}, {"id"=>"D000998", "term"=>"Antiviral Agents"}, {"id"=>"D000890", "term"=>"Anti-Infective Agents"}, {"id"=>"D007155", "term"=>"Immunologic Factors"}], "browseLeaves"=>[{"id"=>"M7102", "name"=>"Dexamethasone", "asFound"=>"First", "relevance"=>"HIGH"}, {"id"=>"M235549", "name"=>"Dexamethasone acetate", "relevance"=>"LOW"}, {"id"=>"M199152", "name"=>"BB 1101", "relevance"=>"LOW"}, {"id"=>"M10407", "name"=>"Interferons", "asFound"=>"Including", "relevance"=>"HIGH"}, {"id"=>"M19243", "name"=>"Interferon-alpha", "asFound"=>"Traditional", "relevance"=>"HIGH"}, {"id"=>"M266317", "name"=>"Interferon-alfa-1b", "relevance"=>"LOW"}, {"id"=>"M4217", "name"=>"Anti-Inflammatory Agents", "relevance"=>"LOW"}, {"id"=>"M4251", "name"=>"Antiemetics", "relevance"=>"LOW"}, {"id"=>"M8881", "name"=>"Gastrointestinal Agents", "relevance"=>"LOW"}, {"id"=>"M9047", "name"=>"Glucocorticoids", "relevance"=>"LOW"}, {"id"=>"M9789", "name"=>"Hormones", "relevance"=>"LOW"}, {"id"=>"M9788", "name"=>"Hormone Antagonists", "relevance"=>"LOW"}, {"id"=>"M20966", "name"=>"Antineoplastic Agents, Hormonal", "relevance"=>"LOW"}, {"id"=>"M4314", "name"=>"Antiviral Agents", "relevance"=>"LOW"}, {"id"=>"M4214", "name"=>"Anti-Infective Agents", "relevance"=>"LOW"}, {"id"=>"M10201", "name"=>"Immunologic Factors", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Anti-Inflammatory Agents", "abbrev"=>"Infl"}, {"name"=>"Antineoplastic Agents", "abbrev"=>"ANeo"}, {"name"=>"Antiemetics", "abbrev"=>"AnEm"}, {"name"=>"Gastrointestinal Agents", "abbrev"=>"Gast"}, {"name"=>"All Drugs and Chemicals", "abbrev"=>"All"}, {"name"=>"Anti-Infective Agents", "abbrev"=>"Infe"}]}}, "protocolSection"=>{"designModule"=>{"phases"=>["PHASE2"], "studyType"=>"INTERVENTIONAL", "designInfo"=>{"allocation"=>"NA", "maskingInfo"=>{"masking"=>"NONE"}, "primaryPurpose"=>"TREATMENT", "interventionModel"=>"SINGLE_GROUP"}, "enrollmentInfo"=>{"type"=>"ACTUAL", "count"=>93}}, "statusModule"=>{"overallStatus"=>"COMPLETED", "startDateStruct"=>{"date"=>"1996-11"}, "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2015-03", "completionDateStruct"=>{"date"=>"2000-07", "type"=>"ACTUAL"}, "lastUpdateSubmitDate"=>"2015-03-05", "studyFirstSubmitDate"=>"1999-11-01", "studyFirstSubmitQcDate"=>"2003-01-26", "lastUpdatePostDateStruct"=>{"date"=>"2015-03-06", "type"=>"ESTIMATED"}, "studyFirstPostDateStruct"=>{"date"=>"2003-01-27", "type"=>"ESTIMATED"}, "primaryCompletionDateStruct"=>{"date"=>"1998-12", "type"=>"ACTUAL"}}, "outcomesModule"=>{"primaryOutcomes"=>[{"measure"=>"response", "timeFrame"=>"10 months", "description"=>"50% or more reduction in quantitative immunoglobulin, or if the patient has light-chain disease only, a 50% or more reduction in the urine M-component (Bence-Jones protein)."}]}, "oversightModule"=>{"oversightHasDmc"=>true}, "conditionsModule"=>{"keywords"=>["primary systemic amyloidosis"], "conditions"=>["Multiple Myeloma"]}, "referencesModule"=>{"references"=>[{"pmid"=>"15308571", "type"=>"RESULT", "citation"=>"Dhodapkar MV, Hussein MA, Rasmussen E, Solomon A, Larson RA, Crowley JJ, Barlogie B; United States Intergroup Trial Southwest Oncology Group. Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628. Blood. 2004 Dec 1;104(12):3520-6. doi: 10.1182/blood-2004-05-1924. Epub 2004 Aug 12."}, {"type"=>"RESULT", "citation"=>"Dhodapkar M, Jacobson J, Hussein M, et al.: High dose dexamethasone (Dex) with maintenance Dex / alpha interferon leads to improved survival in patients with primary systemic amyloidosis: results of US Intergroup Trial Southwest Oncology Group (SWOG) S9628. [Abstract] Proceedings of the American Society of Clinical Oncology 22: A-2278, 2003."}]}, "descriptionModule"=>{"briefSummary"=>"RATIONALE: Chemotherapy plus interferon alfa may be effective for primary systemic amyloidosis.\n\nPURPOSE: Phase II trial to study the effectiveness of dexamethasone plus interferon alfa in treating patients who have primary systemic amyloidosis.", "detailedDescription"=>"OBJECTIVES:\n\n* Evaluate M protein and organ dysfunction responses and overall and progression-free survival in patients with primary systemic amyloidosis treated with dexamethasone/interferon alfa.\n* Identify prognostic factors that may relate to response and overall survival in these patients.\n* Evaluate the qualitative and quantitative toxic effects of this regimen.\n\nOUTLINE: Patients are stratified by prior amyloidosis treatment (yes vs no).\n\nAll patients receive induction therapy with oral dexamethasone on days 1-4, 9-12, and 17-20 every 35 days for a total of 3 courses.\n\nMaintenance therapy begins within 5-8 weeks (within 10 weeks if patients undergo stem cell harvest) of initiation of the third course of induction, as follows: oral dexamethasone for 4 days every 4 weeks; and subcutaneous interferon alfa 3 times per week. Patients who achieved less than a 50% reduction in serum M protein or urinary Bence-Jones protein and who experienced less than grade 3 toxicity during induction receive 3 additional courses of pulse dexamethasone concurrently with entry to maintenance therapy and the initiation of interferon alfa.\n\nCombination therapy is continued until 2 years from entry; thereafter, interferon is administered alone for at least 3 years, toxicity permitting. Patients with stable disease after 5 years of therapy may discontinue interferon alfa at the discretion of the treating physician.\n\nPatients are followed every 6 months for 2 years and yearly thereafter.\n\nPROJECTED ACCRUAL: A total of 100 patients (50 with prior melphalan/prednisone or iododoxorubicin treatment and 50 without) will be entered over 3 years."}, "eligibilityModule"=>{"sex"=>"ALL", "stdAges"=>["ADULT", "OLDER_ADULT"], "minimumAge"=>"18 years", "healthyVolunteers"=>false, "eligibilityCriteria"=>"DISEASE CHARACTERISTICS:\n\n* Histologically diagnosed primary systemic amyloidosis based on the following:\n\n * Deposition of fibrillary protein with Congo red positive stain or characteristic electron microscopic appearance\n * Monoclonal light chain protein (Bence-Jones protein) in serum or urine or immunohistochemical studies\n * Evidence of tissue involvement other than carpal tunnel syndrome\n * Diagnostic histologic material available for central pathology review\n\n * Confirmation of tissue diagnosis at all sites of organ dysfunction encouraged\n* No senile, secondary, localized, dialysis-related, or familial amyloidosis\n* No known therapy-related myelodysplasia\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* Adult\n\nPerformance status:\n\n* SWOG 0-4\n\nHematopoietic:\n\n* Not specified\n\nHepatic:\n\n* Not specified\n\nRenal:\n\n* Not specified\n\nCardiovascular:\n\n* No NYHA class IV status\n\nOther:\n\n* No uncontrolled diabetes\n* No active peptic ulcer disease\n* No medical condition that precludes high-dose steroids\n* No second malignancy within 5 years except:\n* Adequately treated nonmelanomatous skin cancer\n* In situ cervical cancer\n* Adequately treated stage I/II cancer in complete remission\n* Not pregnant or nursing\n* Effective contraception required of fertile patients\n* Blood/body fluid analyses within 14 days prior to registration\n* Imaging/exams for tumor measurement within 28 days prior to registration\n* Other screening exams within 42 days prior to registration\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* No prior interferon alfa\n\nChemotherapy\n\n* Prior melphalan allowed, but recovered from effects\n* At least 4 weeks since cytotoxic therapy and recovered\n\nEndocrine therapy\n\n* Prior prednisone allowed, but recovered from effects\n* At least 4 weeks since prior glucocorticoids\n* No prior dexamethasone\n* No planned or concurrent dexamethasone or other therapy for primary systemic amyloidosis\n\nRadiotherapy\n\n* Not specified\n\nSurgery\n\n* Not specified"}, "identificationModule"=>{"nctId"=>"NCT00002849", "briefTitle"=>"S9628 Dexamethasone Plus Interferon Alfa in Treating Patients With Primary Systemic Amyloidosis", "organization"=>{"class"=>"NETWORK", "fullName"=>"SWOG Cancer Research Network"}, "officialTitle"=>"Phase II Study of Dexamethasone/Alpha-Interferon in AL Amyloidosis", "orgStudyIdInfo"=>{"id"=>"S9628"}, "secondaryIdInfos"=>[{"id"=>"S9628", "type"=>"OTHER", "domain"=>"SWOG"}, {"id"=>"CLB-9790", "type"=>"OTHER", "domain"=>"CALGB"}, {"id"=>"CLB-S9628", "type"=>"OTHER", "domain"=>"CALGB"}, {"id"=>"U10CA032102", "link"=>"https://reporter.nih.gov/quickSearch/U10CA032102", "type"=>"NIH"}]}, "armsInterventionsModule"=>{"armGroups"=>[{"type"=>"EXPERIMENTAL", "label"=>"induction and maintenance", "description"=>"dexamethasone induction followed by alpha interferon maintenance", "interventionNames"=>["Biological: recombinant interferon alfa", "Drug: dexamethasone"]}], "interventions"=>[{"name"=>"recombinant interferon alfa", "type"=>"BIOLOGICAL", "otherNames"=>["alpha interferon"], "description"=>"first 2 years", "armGroupLabels"=>["induction and maintenance"]}, {"name"=>"dexamethasone", "type"=>"DRUG", "otherNames"=>["decadron"], "description"=>"40 mg\\*/d PO 1 - 4, 9 - 12, 17-20 q 35 days for 3 cycles\\*", "armGroupLabels"=>["induction and maintenance"]}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"92093-0658", "city"=>"La Jolla", "state"=>"California", "country"=>"United States", "facility"=>"Rebecca and John Moores UCSD Cancer Center", "geoPoint"=>{"lat"=>32.84727, "lon"=>-117.2742}}, {"zip"=>"94121", "city"=>"San Francisco", "state"=>"California", "country"=>"United States", "facility"=>"Veterans Affairs Medical Center - San Francisco", "geoPoint"=>{"lat"=>37.77493, "lon"=>-122.41942}}, {"zip"=>"19899", "city"=>"Wilmington", "state"=>"Delaware", "country"=>"United States", "facility"=>"CCOP - Christiana Care Health Services", "geoPoint"=>{"lat"=>39.74595, "lon"=>-75.54659}}, {"zip"=>"20007", "city"=>"Washington", "state"=>"District of Columbia", "country"=>"United States", "facility"=>"Lombardi Cancer Center", "geoPoint"=>{"lat"=>38.89511, "lon"=>-77.03637}}, {"zip"=>"20307-5000", "city"=>"Washington", "state"=>"District of Columbia", "country"=>"United States", "facility"=>"Walter Reed Army Medical Center", "geoPoint"=>{"lat"=>38.89511, "lon"=>-77.03637}}, {"zip"=>"33140", "city"=>"Miami Beach", "state"=>"Florida", "country"=>"United States", "facility"=>"CCOP - Mount Sinai Medical Center", "geoPoint"=>{"lat"=>25.79065, "lon"=>-80.13005}}, {"zip"=>"60612", "city"=>"Chicago", "state"=>"Illinois", "country"=>"United States", "facility"=>"Veterans Affairs Medical Center - Chicago (Westside Hospital)", "geoPoint"=>{"lat"=>41.85003, "lon"=>-87.65005}}, {"zip"=>"60637-1470", "city"=>"Chicago", "state"=>"Illinois", "country"=>"United States", "facility"=>"University of Chicago Cancer Research Center", "geoPoint"=>{"lat"=>41.85003, "lon"=>-87.65005}}, {"zip"=>"52242-1009", "city"=>"Iowa City", "state"=>"Iowa", "country"=>"United States", "facility"=>"Holden Comprehensive Cancer Center", "geoPoint"=>{"lat"=>41.66113, "lon"=>-91.53017}}, {"zip"=>"21201", "city"=>"Baltimore", "state"=>"Maryland", "country"=>"United States", "facility"=>"Marlene and Stewart Greenebaum Cancer Center, University of Maryland", "geoPoint"=>{"lat"=>39.29038, "lon"=>-76.61219}}, {"zip"=>"02115", "city"=>"Boston", "state"=>"Massachusetts", "country"=>"United States", "facility"=>"Dana-Farber Cancer Institute", "geoPoint"=>{"lat"=>42.35843, "lon"=>-71.05977}}, {"zip"=>"01655", "city"=>"Worcester", "state"=>"Massachusetts", "country"=>"United States", "facility"=>"University of Massachusetts Memorial Medical Center - University Campus", "geoPoint"=>{"lat"=>42.26259, "lon"=>-71.80229}}, {"zip"=>"55417", "city"=>"Minneapolis", "state"=>"Minnesota", "country"=>"United States", "facility"=>"Veterans Affairs Medical Center - Minneapolis", "geoPoint"=>{"lat"=>44.97997, "lon"=>-93.26384}}, {"zip"=>"55455", "city"=>"Minneapolis", "state"=>"Minnesota", "country"=>"United States", "facility"=>"University of Minnesota Cancer Center", "geoPoint"=>{"lat"=>44.97997, "lon"=>-93.26384}}, {"zip"=>"65201", "city"=>"Columbia", "state"=>"Missouri", "country"=>"United States", "facility"=>"Veterans Affairs Medical Center - Columbia (Truman Memorial)", "geoPoint"=>{"lat"=>38.95171, "lon"=>-92.33407}}, {"zip"=>"65203", "city"=>"Columbia", "state"=>"Missouri", "country"=>"United States", "facility"=>"Ellis Fischel Cancer Center - Columbia", "geoPoint"=>{"lat"=>38.95171, "lon"=>-92.33407}}, {"zip"=>"63110", "city"=>"Saint Louis", "state"=>"Missouri", "country"=>"United States", "facility"=>"Barnes-Jewish Hospital", "geoPoint"=>{"lat"=>38.62727, "lon"=>-90.19789}}, {"zip"=>"68198-7680", "city"=>"Omaha", "state"=>"Nebraska", "country"=>"United States", "facility"=>"University of Nebraska Medical Center", "geoPoint"=>{"lat"=>41.25626, "lon"=>-95.94043}}, {"zip"=>"89106", "city"=>"Las Vegas", "state"=>"Nevada", "country"=>"United States", "facility"=>"CCOP - 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Upstate Medical University", "geoPoint"=>{"lat"=>43.04812, "lon"=>-76.14742}}, {"zip"=>"13210", "city"=>"Syracuse", "state"=>"New York", "country"=>"United States", "facility"=>"Veterans Affairs Medical Center - Syracuse", "geoPoint"=>{"lat"=>43.04812, "lon"=>-76.14742}}, {"zip"=>"13217", "city"=>"Syracuse", "state"=>"New York", "country"=>"United States", "facility"=>"CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.", "geoPoint"=>{"lat"=>43.04812, "lon"=>-76.14742}}, {"zip"=>"27599-7295", "city"=>"Chapel Hill", "state"=>"North Carolina", "country"=>"United States", "facility"=>"Lineberger Comprehensive Cancer Center, UNC", "geoPoint"=>{"lat"=>35.9132, "lon"=>-79.05584}}, {"zip"=>"27705", "city"=>"Durham", "state"=>"North Carolina", "country"=>"United States", "facility"=>"Veterans Affairs Medical Center - Durham", "geoPoint"=>{"lat"=>35.99403, "lon"=>-78.89862}}, {"zip"=>"27710", "city"=>"Durham", "state"=>"North Carolina", "country"=>"United States", "facility"=>"Duke Comprehensive Cancer Center", "geoPoint"=>{"lat"=>35.99403, "lon"=>-78.89862}}, {"zip"=>"27104-4241", "city"=>"Winston-Salem", "state"=>"North Carolina", "country"=>"United States", "facility"=>"CCOP - Southeast Cancer Control Consortium", "geoPoint"=>{"lat"=>36.09986, "lon"=>-80.24422}}, {"zip"=>"27157-1082", "city"=>"Winston-Salem", "state"=>"North Carolina", "country"=>"United States", "facility"=>"Comprehensive Cancer Center at Wake Forest University", "geoPoint"=>{"lat"=>36.09986, "lon"=>-80.24422}}, {"zip"=>"43210-1240", "city"=>"Columbus", "state"=>"Ohio", "country"=>"United States", "facility"=>"Arthur G. James Cancer Hospital - Ohio State University", "geoPoint"=>{"lat"=>39.96118, "lon"=>-82.99879}}, {"zip"=>"02906", "city"=>"Providence", "state"=>"Rhode Island", "country"=>"United States", "facility"=>"Lifespan: The Miriam Hospital", "geoPoint"=>{"lat"=>41.82399, "lon"=>-71.41283}}, {"zip"=>"05401-3498", "city"=>"Burlington", "state"=>"Vermont", "country"=>"United States", "facility"=>"Vermont Cancer Center", "geoPoint"=>{"lat"=>44.47588, "lon"=>-73.21207}}, {"zip"=>"05009", "city"=>"White River Junction", "state"=>"Vermont", "country"=>"United States", "facility"=>"Veterans Affairs Medical Center - White River Junction", "geoPoint"=>{"lat"=>43.64896, "lon"=>-72.31926}}, {"zip"=>"23298-0037", "city"=>"Richmond", "state"=>"Virginia", "country"=>"United States", "facility"=>"MBCCOP - Massey Cancer Center", "geoPoint"=>{"lat"=>37.55376, "lon"=>-77.46026}}], "overallOfficials"=>[{"name"=>"Laura F. Hutchins, MD", "role"=>"STUDY_CHAIR", "affiliation"=>"University of Arkansas"}, {"name"=>"Richard A. Larson, MD", "role"=>"STUDY_CHAIR", "affiliation"=>"University of Chicago"}]}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"SWOG Cancer Research Network", "class"=>"NETWORK"}, "collaborators"=>[{"name"=>"National Cancer Institute (NCI)", "class"=>"NIH"}, {"name"=>"Cancer and Leukemia Group B", "class"=>"NETWORK"}], "responsibleParty"=>{"type"=>"SPONSOR"}}}}