Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction

Launched by NORTHWESTERN UNIVERSITY · May 8, 2003

Keywords

ClinConnect Summary

OBJECTIVES:

* Determine the objective response and clinical outcome in patients with duodenal obstruction secondary to malignancy treated with enteral Wallstents.
* Evaluate the efficacy and safety of this treatment in these patients.
* Evaluate the quality of life of these patients after enteral Wallstent placement.

OUTLINE: Patients undergo enteral Wallstent placement through an endoscope under fluoroscopic guidance into the duodenum.

Quality of life is assessed at 48 hours and 6 months after procedure.

Patients are followed at 48 hours, 30 days, 6 months, and then yearly thereafter u...

Gender

ALL

Eligibility criteria

• DISEASE CHARACTERISTICS:
• • Endoscopically confirmed localized tumor as the cause of duodenal obstruction
• • All primary tumor types are eligible
• • No prior duodenal Wallstents
• * Must have symptoms of gastrointestinal obstruction, including:
• • Inability to move bowels, absence of flatus, nausea/vomiting, abdominal pain, or diarrhea
• PATIENT CHARACTERISTICS:
• Age:
• • 18 and over
• Performance status:
• • ECOG 0-3
• Life expectancy:
• • Not specified
• Hematopoietic:
• • Platelet count greater than 50,000/mm\^3
• Hepatic:
• • INR no greater than 1.5 times upper limit of normal
• Renal:
• • Not specified
• Cardiovascular:
• • No cardiac condition
• Other:
• • Not pregnant or nursing
• • Fertile patients must use effective contraception
• • No significant active infection (e.g., pneumonia, peritonitis, or wound abscess) that would preclude endoscopy
• • No other serious concurrent illness
• • No uncontrolled metabolic disease (e.g., diabetes mellitus or hypothyroidism)
• • No dementia, psychiatric disorder, or altered mental status that would preclude compliance
• • History of other neoplastic disease allowed
• • Veterans Administration patients are not eligible
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• • Not specified
• Chemotherapy:
• • Prior or concurrent chemotherapy allowed
• Endocrine therapy:
• • Not specified
• Radiotherapy:
• • Prior or concurrent radiotherapy allowed
• Surgery:
• • At least 3 weeks since prior surgery and recovered