Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer

Launched by NATIONAL CANCER INSTITUTE (NCI) · Nov 22, 2000

Keywords

ClinConnect Summary

This clinical trial is focused on collecting blood and tissue samples from individuals who have HIV, Kaposi's sarcoma, or certain types of cancer. The goal is to better understand these conditions and how they might be linked to infections caused by specific viruses. By studying these samples, researchers hope to make important scientific advances that could lead to better treatments and outcomes for patients.

To participate in this trial, you need to be at least 18 years old and meet certain criteria, such as being HIV positive or having been exposed to HIV or other related viruses. Participants will have blood drawn during their visits, and may also provide other samples like urine or tissue from tumors if it's safe to do so. If you decide to join, you'll be fully informed about any risks involved, and your health and safety will be the top priority throughout the study.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Age 18 years or older.
• • ECOG performance status less than or equal to 3
• At least one of the following:
• • Exposure risk to HIV, KSHV, or HPV
• • HIV seropositive
• • KSHV seropositive
• • EBV seropositive
• • HTLV-1 seropositive
• • NOTE: infection with HIV, KSHV, EBV, and HTLV-1 are life-long, so if participants have previously been seropositive or have had a disease associated with KSHV (KS, primary effusion lymphoma \[PEL\], or KSHV-multicentric Castleman s disease \[MCD\]), this is sufficient to meet this criterion for eligibility.
• • Malignancy, MCD, or skin lesions with appearance of KS
• • Cervical or anal intraepithelial lesion
• • Ability of participant to understand and the willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• • None