Phenotype/Genotype Correlations in Movement Disorders

Launched by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) · Jul 7, 2001

Keywords

ClinConnect Summary

This clinical trial is focused on understanding movement disorders, which are conditions that affect a person's ability to control their movements. The researchers want to identify families who have these inherited movement disorders and learn more about how the disease shows up in different people. By using the latest technology, they aim to make accurate diagnoses and explore the genetic factors behind these conditions. This study is especially valuable for families with a strong history of movement disorders, as it may help identify specific genes that cause these diseases.

To participate, individuals with movement disorders or their family members can join the study, as long as they can provide consent or have someone to help them with that. Participants will undergo evaluations that may include genetic testing and possibly imaging studies. It's important to note that some individuals, like pregnant women or very young children, may not be eligible for certain tests. Overall, the trial aims to gather important information that could lead to better understanding and treatment of movement disorders in the future.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Individuals with suspected movement disorders
• • Family members of movement disorders patients
• • Ability to give informed consent or have a legally authorized representative able to give consent (for adults without consent capacity) or parent/guardian able to provide informed consent (for a child)
• • If unable to give informed consent, ability to give assent (for children or adults without consent capacity)
• • NIH Employees can participate in this study if they meet eligibility.
• EXCLUSION CRITERIA:
• • Pregnant women
• • Children less than 2 years of age
• • Employees of the Parkinson's Disease Clinic, NINDS
• • Exclusion criteria for MRI
• • Presence of metal in subject s body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if subject was a welder or metal worker, since small metal fragments in the eye may be present.
• • Subject is uncomfortable in small closed spaces (have claustrophobia) so that they would feel uncomfortable in the MRI machine.
• • Unable to lie comfortably on back for up to 1 hour
• • Under 12 years of age
• • There is no general exclusion for NIH employees.