A Natural History Study of Bone and Mineral Disorders

Launched by NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH (NIDCR) · Sep 28, 2001

Keywords

ClinConnect Summary

This clinical trial is focused on understanding and studying various bone and mineral disorders, including conditions like Tumor Induced Osteomalacia, Osteomalacia, and Familial Tumoral Calcinosis. The goal is to collect bone samples and gather more knowledge about these conditions to improve care and treatment options for patients with skeletal diseases. If you or someone you know has a known or suspected bone disease or mineral metabolism disorder, you may be eligible to participate in this study.

To qualify, participants must be at least one day old and show signs of bone problems, such as fractures or abnormal findings on imaging tests like X-rays or MRIs. They may also have abnormal levels of minerals in their blood or urine. If you join the study, you will undergo standard medical evaluations, which may include a medical history review, physical exams, and routine tests. Bone samples will be collected during any necessary surgical procedures or through a small biopsy if needed. This study does not involve any experimental treatments, but it aims to enhance our understanding of bone health for everyone involved.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• The study population will include participants with known or suspected bone disease and/or with a known or suspected disorder of mineral metabolism. To be eligible to participate in this study, an individual must meet all of the following criteria:
• • 1. Age 1 day of life or older
• • 2. Have a known or suspected bone disease, as demonstrated by any one of the following: a fracture, or abnormal bone findings on x-ray, CT scan, MRI, or bone densitometry, and/or a medical or family history consistent with or suggestive of a bone disease.
• • 3. Have a known or suspected disorder of mineral metabolism, as demonstrated by any one of the following: laboratory measurement above or below the reference values for either blood or urine calcium, phosphorus, magnesium, parathyroid hormone or vitamin D, or other measures of mineral metabolism, and/or a medical or family history consistent with or suggestive of a disorder of mineral metabolism.
• EXCLUSION CRITERIA:
• • 1. Participants unwilling or unable to abide by procedures of protocol.