Search for New Methods to Detect Acute Renal Failure

Launched by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) · Nov 14, 2001

Keywords

ClinConnect Summary

This clinical trial is looking for new ways to find out if someone has acute kidney failure, which is when the kidneys suddenly stop working properly. The researchers want to discover specific proteins in blood and urine that would show kidney damage, helping to distinguish between healthy individuals and those with kidney issues. The study is open to adults and children aged 3 and older who fit into one of four groups: healthy individuals with normal kidney function, those who are dehydrated (which can be easily treated), people at high risk for kidney failure, or patients who already have acute kidney failure.

Participants in the study will undergo a health check-up and may have up to four blood samples taken, along with urine collection for testing. The time spent in the study will vary: healthy participants will be involved for just one day, while those with dehydration will participate for three days. Patients at high risk or with acute kidney failure will stay for a duration depending on their health needs. The goal of this research is to create better and earlier ways to diagnose kidney problems, which could lead to faster treatment and better recovery outcomes.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • 1. Subjects \>= 3 years old. Both male and female subjects will be recruited without regard to race or ethnic origin.
• 2. Either:
• • 1. Normal (creatinine level \< 1.3 mg/dl for adults; creatinine level \< standard nomogram for children), OR
• • 2. Oliguria due to volume depletion (indicated by oliguria and Fractional Excretion of Sodium (FENa) of less than 1%), OR
• • 3. High risk of ARF, including surgery, transplantation, nephrotoxic antibiotics, or bone marrow transplant. OR
• • 4. Evidence of ARF as defined by an acute progressive rise in serum creatinine (at least 50% increase within 24 hours preceding enrollment) without stabilization or recovery, despite optimization of hemodynamic fluid status and correction of any known pharmacologic, pre-renal, or post-renal etiologic factors. OR
• • 5. Urinary tract infection (to serve as control for ARF studies), OR
• • 6. Established chronic kidney disease (to serve as control for ARF studies).
• EXCLUSION CRITERIA:
• • 1. Minors who do not give clear assent, even with parental consent
• • 2. Existence of any other condition which would complicate the implementation or interpretation of the study.