Study of Factors Regulating Mast Cell Proliferation

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 17, 2002

Keywords

ClinConnect Summary

This clinical trial is studying how certain factors affect the growth of mast cells in the body, which can lead to a condition called mastocytosis. Mastocytosis involves having too many mast cells, which can cause uncomfortable symptoms like itching, rashes, bone pain, and stomach issues. The study is looking to understand what helps these cells grow and what might stop them from growing.

If you or a family member has mastocytosis and are between 2 and 80 years old, you might be eligible to participate in this one-day study at the NIH Clinical Center. Participants will spend up to 8 hours there, going through a series of tests, including a physical exam, blood tests, and a procedure to collect a small sample of bone marrow. This study aims to evaluate your mastocytosis and could provide important insights into the condition. Remember, you will need to be under the care of a primary doctor to join, and the study is currently recruiting participants.

Gender

ALL

Eligibility criteria

• * PATIENT PARTICIPANT INCLUSION CRITERIA:
• • Participants with mastocytosis zero to 80 years of age may participate in telehealth visits, and two to 80 years of age may participate on-site at NIH Clinical Center.
• • Histologic evidence of increased mast cell number by bone marrow and/or skin biopsy or documentation of mastocytosis in the skin
• • supported with a photograph of diagnostic skin lesions
• • Must be under the care of a primary care physician to be enrolled.
• • Ability to provide informed consent.
• PATIENT PARTICIPANT EXCLUSION CRITERIA:
• • Anemia with hemoglobin less than 8 g/dL, hematocrit less than 24.
• • Any condition that in the opinion of the investigator contraindicates participation in this study.
• RELATIVE INCLUSION CRITERIA:
• • Two to 80 years of age.
• • A biological relative without the diagnosis of mastocytosis by skin examination or histologic evidence in a skin or bone marrow biopsy
• • Participant has a primary medical care provider outside the NIH
• • Ability to provide informed consent.
• RELATIVE EXCLUSION CRITERIA:
• • Any condition that in the opinion of the investigator contraindicates participation in this study.