A Study of Capecitabine (Xeloda) and Bevacizumab as a First-line Therapy in Patients With Metastatic Colorectal Cancer
Launched by HOFFMANN-LA ROCHE · Sep 17, 2003
Trial Information
Current as of August 11, 2025
Completed
Keywords
ClinConnect Summary
This study was conducted in 2 parts: An initial 2-arm part in which patients were randomized to 1 of 2 different treatment groups (XELOX or FOLFOX-4), and a subsequent 2 x 2 factorial part, added to the study through a protocol amendment, in which additional patients were randomized into one of 4 different treatment groups (XELOX + placebo, FOLFOX-4 + placebo, XELOX + bevacizumab, or FOLFOX-4 + bevacizumab). Due to the comparison of the oral agent capecitabine with bolus and infused fluorouracil, the study was not blinded with respect to these 2 treatments. The study was double-blind with r...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult patients ≥ 18 years of age.
- • Metastatic colorectal cancer.
- • ≥ 1 target lesion.
- Exclusion Criteria:
- • Previous treatment with oxaliplatin or bevacizumab.
- • Previous systemic chemotherapy or immunotherapy for advanced or metastatic disease.
- • Progressive disease during or within 6 months of completion of previous adjuvant therapy.
About Hoffmann La Roche
Hoffmann-La Roche, commonly known as Roche, is a global leader in biotechnology and pharmaceuticals, committed to advancing healthcare through innovative research and development. With a strong focus on oncology, immunology, infectious diseases, and central nervous system disorders, Roche leverages cutting-edge science to deliver transformative therapies and diagnostics. The company is dedicated to improving patient outcomes by conducting rigorous clinical trials and collaborating with healthcare professionals and organizations worldwide. Roche's unwavering commitment to precision medicine and personalized healthcare positions it at the forefront of the industry, driving progress in the quest for effective treatments and improved patient care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Fountain Valley, California, United States
Adelaide, , Australia
Fitzroy, , Australia
Kurralta Park, , Australia
Perth, , Australia
Port Macquarie, , Australia
St. Leonards, , Australia
Wien, , Austria
Calgary, Alberta, Canada
Kelowna, British Columbia, Canada
Winnipeg, Manitoba, Canada
Ottawa, Ontario, Canada
Regensburg, , Germany
Petach Tikva, , Israel
Genova, , Italy
Modena, , Italy
Lisboa, , Portugal
Madrid, , Spain
Bern, , Switzerland
Aberdeen, , United Kingdom
Cardiff, , United Kingdom
Glasgow, , United Kingdom
Guildford, , United Kingdom
Northwood, , United Kingdom
Plymouth, , United Kingdom
Salisbury, , United Kingdom
Southampton, , United Kingdom
Chicago, Illinois, United States
Scarborough, Maine, United States
Box Hill, , Australia
Edmonton, Alberta, Canada
Victoria, British Columbia, Canada
Oshawa, Ontario, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Beijing, , China
Shanghai, , China
Wuhan, , China
Nice, , France
Trier, , Germany
Hong Kong, , Hong Kong
Haifa, , Israel
Tel Aviv, , Israel
Mexico City, , Mexico
St Petersburg, , Russian Federation
Córdoba, , Spain
Valencia, , Spain
Stockholm, , Sweden
Istanbul, , Turkey
Izmir, , Turkey
Lexington, Kentucky, United States
Vancouver, British Columbia, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
New Orleans, Louisiana, United States
Syracuse, New York, United States
Charlotte, North Carolina, United States
Fargo, North Dakota, United States
Upland, Pennsylvania, United States
Charleston, South Carolina, United States
Richmond, Virginia, United States
Birmingham, , United Kingdom
Taunton, , United Kingdom
Edmonton, Alberta, Canada
Los Angeles, California, United States
San Diego, California, United States
New York, New York, United States
Houston, Texas, United States
Jerusalem, , Israel
Parma, , Italy
Hamilton, Ontario, Canada
Memphis, Tennessee, United States
Pierre Benite, , France
New Brunswick, New Jersey, United States
Sayre, Pennsylvania, United States
Pavia, , Italy
Reggio Emilia, , Italy
Barcelona, , Spain
Zaragoza, , Spain
San Diego, California, United States
Providence, Rhode Island, United States
Las Vegas, Nevada, United States
Santander, , Spain
Newcastle Upon Tyne, , United Kingdom
Hannover, , Germany
Los Angeles, California, United States
Orange, California, United States
Seoul, , Korea, Republic Of
Taipei, , Taiwan
Tampa, Florida, United States
Waterbury, Connecticut, United States
New Orleans, Louisiana, United States
Halifax, Nova Scotia, Canada
Palo Alto, California, United States
Gainesville, Florida, United States
Jacksonville, Florida, United States
Lexington, Kentucky, United States
Boston, Massachusetts, United States
Ann Arbor, Michigan, United States
Rio De Janeiro, , Brazil
Sao Paulo, , Brazil
Berkeley, California, United States
Fullerton, California, United States
Gilroy, California, United States
Greenbrae, California, United States
Norwich, Connecticut, United States
Boca Raton, Florida, United States
Gainesville, Florida, United States
Jacksonville, Florida, United States
New Port Richey, Florida, United States
Atlanta, Georgia, United States
Chicago, Illinois, United States
Elk Grove Village, Illinois, United States
Peoria, Illinois, United States
Boston, Massachusetts, United States
Ann Arbor, Michigan, United States
St Louis Park, Minnesota, United States
East Orange, New Jersey, United States
Hamilton, New Jersey, United States
Albuquerque, New Mexico, United States
Farmington, New Mexico, United States
New York, New York, United States
Rochester, New York, United States
Bismarck, North Dakota, United States
Columbia, South Carolina, United States
Houston, Texas, United States
Burlington, Vermont, United States
Brisbane, , Australia
Camperdown, , Australia
Footscray, , Australia
Malvern, , Australia
Melbourne, , Australia
Sydney, , Australia
Wels, , Austria
Jaú, , Brazil
Rio De Janeiro, , Brazil
Sao Paulo, , Brazil
North Vancouver, British Columbia, Canada
Surrey, British Columbia, Canada
Vancouver, British Columbia, Canada
London, Ontario, Canada
Mississauga, Ontario, Canada
St. Catharines, Ontario, Canada
Levis, Quebec, Canada
Quebec City, Quebec, Canada
Guangdong, , China
Guangzhou, , China
Jiangsu, , China
Jiangxi, , China
Shandong, , China
Tianjin, , China
Brno, , Czech Republic
Chomutov, , Czech Republic
Hradec Kralove, , Czech Republic
Ostrava, , Czech Republic
Herlev, , Denmark
København, , Denmark
Odense, , Denmark
Helsinki, , Finland
Tampere, , Finland
Turku, , Finland
Besancon, , France
Bobigny, , France
Boulogne Billancourt, , France
Brest, , France
Chambray Les Tours, , France
Colmar, , France
Dijon, , France
Grenoble, , France
Lyon, , France
Metz, , France
Nimes, , France
Paris, , France
Rouen, , France
Saint Herblain, , France
Toulouse, , France
Bochum, , Germany
Halle, , Germany
Herne, , Germany
Leipzig, , Germany
Mainz, , Germany
Mannheim, , Germany
Stralsund, , Germany
Guatemala City, , Guatemala
Guatemala, , Guatemala
Budapest, , Hungary
Gyor, , Hungary
Kecskemet, , Hungary
Cork, , Ireland
Dublin, , Ireland
Galway, , Ireland
Zerifin, , Israel
Ancona, , Italy
Padova, , Italy
Sassari, , Italy
Christchurch, , New Zealand
Bergen, , Norway
Oslo, , Norway
Tromsø, , Norway
Panama City, , Panama
Beja, , Portugal
San Juan, , Puerto Rico
Moscow, , Russian Federation
Cape Town, , South Africa
Pretoria, , South Africa
Sandton, , South Africa
Granada, , Spain
Leganes, , Spain
Málaga, , Spain
Gaevle, , Sweden
Karlstad, , Sweden
Uppsala, , Sweden
Västerås, , Sweden
Geneve, , Switzerland
Kueishan, , Taiwan
Bangkok, , Thailand
Khon Kaen, , Thailand
Derby, , United Kingdom
Hull, , United Kingdom
London, , United Kingdom
Maidstone, , United Kingdom
Nottingham, , United Kingdom
Sutton, , United Kingdom
Patients applied
Trial Officials
Clinical Trials
Study Director
Hoffmann-La Roche
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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