Urinary Vitamin C Loss in Diabetic Subjects

Launched by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) · Oct 27, 2003

Keywords

ClinConnect Summary

This clinical trial is investigating the levels of vitamin C in people with diabetes and how their bodies handle it compared to those without diabetes. Previous research has suggested that people with diabetes may have lower levels of vitamin C in their blood but higher levels in their urine. However, the reasons for this are not well understood. By studying individuals with and without diabetes, the researchers aim to find out if diabetes affects how the body absorbs and loses vitamin C, as well as exploring genetic factors that might play a role.

To participate in this study, you need to be between 18 and 65 years old and either have diabetes (Type 1 or Type 2) or be a healthy control without diabetes. Participants will have their vitamin C levels measured in blood and urine, and some may be invited for a more detailed study at the Clinical Center. It’s important to know that certain health conditions or being pregnant may disqualify you from participating. Overall, this research could help improve our understanding of vitamin C in diabetes and lead to better care for those affected by this condition.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• To be included in the study, study subjects should be:
• • Aged 18-65 years.
• * Either:
• • Have no diagnosis of diabetes: "nondiabetic controls", or
• • Have a diagnosis in their medical history of either Type 1 or Type 2 diabetes
• • EXCLUSION CRITERIA (for outpatient study, arm 1)
• Exclusion criteria will include the following:
• • Unable or unwilling to provide a signed and dated informed consent form
• • Unable or unwilling to comply with study procedures and lifestyle considerations
• • EXCLUSION CRITERIA (for inpatient studies, arms 2 and 3)
• Study participants interested in participating in Arms 2 and/or 3 will be excluded from this further participation if they meet any of the following:
• • significant organ malfunction leading to clinical instability including liver disease, pulmonary disease, ischemic heart disease, heart failure, stroke, peripheral vascular disease, and anemia at investigator discretion
• • other serious or chronic illness; history of serious or chronic illness; coronary artery disease, or peripheral vascular disease resulting in clinical instability
• • pregnancy or lactation
• • presence of other conditions which, in the judgment of the investigators, can influence vitamin C metabolism or vitamin C renal handling