Family Study of Affective and Anxiety Spectrum Disorders

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Oct 30, 2003

Keywords

ClinConnect Summary

This clinical trial is looking into how mood disorders like depression and anxiety, as well as migraines, affect families. The goal is to understand how these conditions are passed down through generations and to identify risk factors that can lead to physical and mental health issues. By studying family members of all ages, including children aged 8 to 17, researchers hope to find ways to prevent and treat these problems.

To participate, individuals should be able to understand the interview questions and be willing to involve at least two family members. Participants will spend about 3 to 4 hours answering questions about their health, relationships, and how they cope with stress. The study team may visit homes or conduct interviews over the phone. This research will not only help identify patterns of mood disorders across different ages but also invite families to take part in future studies that track these issues over time.

Gender

ALL

Eligibility criteria

• • Since this study is based on systematic recruitment from the local community and other non-clinical settings such as screening protocols from volunteers, there are no specific diagnostic inclusion and exclusion criteria. However, the study targets individuals with mood spectrum conditions and migraine. Criteria for the specific subgroups of mood and anxiety disorders are presented in Table 1. Individuals who do not meet criteria are classified as controls.
• INCLUSION CRITERIA:
• • 1. the ability to comprehend the interview, and
• • 2. probands must agree to contact at least two relatives (contacting relatives is not required in cases where the participant is enrolled in just the mobile technologies assessments (EMA and Actigraphy).
• EXCLUSION CRITERIA:
• • The only exclusion criteria include impaired ability to comprehend the interview or inability to read.
• SPECIFIC INCLUSION AND EXCLUSION CRITERIA BY PROBAND GROUP:
• GENERAL INCLUSION CRITERIA:
• • The only inclusion criteria for the study are that the person be English-speaking and ability to read and comprehend the interview.
• BIPOLAR I INCLUSION CRITERIA:
• • Lifetime history of DSM-IV Bipolar I or Manic Episode
• BIPOLAR II INCLUSION CRITERIA:
• • Lifetime history of DSM-IV Bipolar II with duration of hypomania reduced to 2 or more days (according to RDC)
• MAJOR DEPRESSION INCLUSION CRITERIA:
• • Lifetime history of at least 2 episodes of DSM-IV Major Depression
• PANIC/GAD INCLUSION CRITERIA:
• • Lifetime history of DSM-IV diagnosis for Panic Disorder or GAD
• PHOBIAS INCLUSION CRITERIA:
• • Lifetime history of DSM-IV diagnosis for social anxiety disorder, agoraphobia, or specific phobias (greater than or equal to 3)
• MIGRAINE INCLUSION CRITERIA:
• • Lifetime history of IHS migraine with or without Aura
• GENERAL EXCLUSION CRITERIA:
• • The only exclusion criteria include impaired ability to comprehend the interview or inability to read.