A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Sep 17, 2004

Keywords

ClinConnect Summary

This clinical trial is studying a condition called familial hypereosinophilia (FE), which is a hereditary form of hypereosinophilic syndrome (HES). In HES, a type of white blood cell called eosinophils can become too high in number, potentially causing damage to the heart, nerves, and other organs. The goal of this research is to understand the causes and effects of FE better, which can help in developing safer and more effective treatments for those affected.

To participate in this study, individuals must be aged 1 to 100 and be a genetically related member of a family already identified with FE. Participants will undergo yearly check-ups that include medical history reviews, physical exams, blood tests, and other tests to monitor their health. They will also provide blood and tissue samples for research. This study is open to both adults and children, and there may be additional procedures for adults, like donating bone marrow or undergoing a special blood donation process. Participants should be willing to commit to the study for an extended period and follow all procedures.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• In order to be eligible to participate in this study, an individual must meet all of the following criteria:
• • Stated willingness to comply with all study procedures and availability for the duration of the study
• • Male or female, aged 1-100 years of age
• • Genetically related member of a previously identified family with FE
• • Ability of subject to understand and the willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• An individual who meets any of the following criteria will be excluded from participation in this study:
• • Any condition that the investigator feels put the subject at unacceptable risk for participation in the study
• • Pregnancy (in family members who do not have eosinophilia)