Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers
Launched by IMPERIAL COLLEGE LONDON · Sep 7, 2005
Trial Information
Current as of September 26, 2025
Completed
Keywords
ClinConnect Summary
The study was about exploring the influence of zinc carnosine (ZnC) on changes in small bowel permeability caused by indomethacin.
Healthy volunteers (n = 10) participated in this double-blind randomised controlled crossover protocol. Each arm comprised two baseline urine collections, followed by a third at the end of that study period. In each arm, volunteers took ZnC (37.5 mg twice daily, orally) or placebo for 7 days, with indomethacin for the final 5 days.
Results were expressed as lactulose:rhamnose (L:R) ratios and mean values for each stage were therefore estimated: when taking pla...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Aged 18-35 years
- Exclusion Criteria:
- • Conditions known to alter intestinal permeability, eg previous bowel surgery, celiac disease
- • Conditions where NSAIDs are contraindicated, eg asthma, renal failure, heart failure
- • Diabetes
- • Any other serious illness
About Imperial College London
Imperial College London is a world-renowned research institution based in the United Kingdom, recognized for its commitment to advancing medical science and improving patient care through innovative research and clinical trials. With a strong emphasis on interdisciplinary collaboration, Imperial combines expertise across various fields, including medicine, engineering, and business, to drive breakthroughs in healthcare. The institution’s robust clinical trial programs are designed to evaluate new therapies and interventions, ensuring rigorous scientific standards and ethical practices while aiming to translate research findings into tangible benefits for patients and society.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
London, United Kingdom
Patients applied
Trial Officials
Raymond Playford, MD, PhD
Principal Investigator
Imperial College London
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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