Facial Thermography Study of Levocetirizine Versus Cetirizine

Launched by UCB PHARMA · Sep 6, 2005

Keywords

ClinConnect Summary

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Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy male Caucasian subject aged between 18 and 55 years (both inclusive).
• • Subject must have a positive prick test to histamine (wheal diameter ≥ 6 mm with histamine dihydrochloride (100 mg/mL) and ≤ 3 mm with diluent control).
• Exclusion Criteria:
• • History of allergic disease, documented or suspected, including but not limited to: asthma, whether or not considered as allergic; nocturnal cough episode suspected to be of asthma-equivalent nature (three or more consecutive nights resulting in sleep disturbances) ; allergic rhinitis, conjunctivitis or sinusitis; nasal polyposis; dermatitis of the face or neck; drug or food allergy.
• • Any clinically significant vascular disease such as hyper- or hypotension, venous disorder, vasculitis etc.
• • History of hot flushes and any other vasomotor disorders.
• • ENT infection or Upper Respiratory Tract Infection not completely cured at least one week before inclusion.
• • Any known history of laryngeal edema.
• • Nasal structural abnormalities (e.g. deviation of the nasal septum...).
• • Recent immunotherapy
• • Skin irritants or UV exposure 48 hours before each visit.