Markers for Chronic Obstructive Pulmonary Disease (COPD)

Launched by IMPERIAL COLLEGE LONDON · Sep 9, 2005

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy non-smokers
• • FEV1 \>80% predicted
• • FEV1 reversibility of \<10% after inhaled (beta2-agonists
• • Current smokers
• • FEV1 no less than 80% predicted
• • FEV1 reversibility of \<10% after inhaled (beta2-agonists
• • Smoking history of \> 10 pack-years
• • Moderate COPD
• • FEV1 40-59% predicted
• • FEV1 reversibility of \<10% after inhaled (beta2-agonists
• • Smoking history of \> 10 pack-years\*\*
• • Severe COPD
• • FEV1 \<40% predicted
• • FEV1 reversibility of \<10% after inhaled (beta2-agonists
• • Smoking history of \> 10 pack-years
• Exclusion Criteria:
• • FEV1 increases by 200 ml and 15% of the baseline value after inhaled (beta2-agonists
• • Asthma
• • unstable disease (FEV1 \<35% predicted) and/or current, or within the last 4 weeks, respiratory tract infection.

Trial Officials