German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Launched by GOETHE UNIVERSITY · Sep 12, 2005

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of acute lymphoblastic leukemia (pro B, pre B, c-ALL or T-ALL), proved by morphology and immunophenotyping
• • Age \> 55 yrs (no upper age limit)
• • Written informed consent
• Exclusion Criteria:
• • Severe leukemia associated complications, not controllable before therapy onset e.g.
• • life threatening infections as sepsis, pneumonia, hypoxia, shock, life threatening bleeding)
• • Severe comorbidity e.g.
• • decompensated renal failure if not caused by leukemia with Creatinine \> 2x ULN
• • heart failure (NYHA II/IV), instable Angina, significant coronary stenosis
• • hepatic insufficiency e.g. liver cirrhosis or chronic active hepatitis with bilirubin \> 1,5 x ULN and/or ASA, ALA, AP \> 2,5 ULN
• • decompensated metabolic disturbances (e.g. not controllable diabetes)
• • severe obstructive or restrictive pulmonary disease with hypoxaemia
• • Severe psychiatric illness or other circumstances which may compromise cooperation of the patient
• • Active second neoplasia
• • HIV infection
• • Severely reduced general condition
• • Cytostatic pre-treatment of ALL
• • Chemotherapy treatment of any other malignancy during the last 5 years
• • Participation in other clinical trials interfering with the study therapy