Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients

Launched by MASSACHUSETTS GENERAL HOSPITAL · Sep 19, 2005

Keywords

ClinConnect Summary

Proline is a nutritionally dispensable (non-essential) amino acid. Its synthesis and catabolism is via the pathway of ornithine and glutamate. The latter two amino acids serve as immediate precursors for proline, as well as metabolites. Ornithine is one of the intermediates for urea cycle. Glutamate is metabolically connected to tricarboxylic acid (TCA) cycle, the major cycle for energy production.

It is hypothesized that the significantly increased rates of net nitrogen loss and energy "production", as the consequence of the accelerated activities of both the urea and TCA cycles in burn i...

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Eligibility criteria

• Inclusion Criteria:
• • Burn patients being treated at MGH Burn Unit with one or more of the following criteria: 1) \>=5% TBSA; 2) inhalation injury; or 3) resting energy expenditure (REE) of \>15% of the predicted Basal Metabolic Rate using the Harris-Benedict equation.
• • Must be receiving total parenteral nutrition in the course of their treatment.
• Exclusion Criteria:
• • Patients with thyroid disease. Patients who are not hemodynamically stable or show unstable vital signs Patients at the stage of major organ failure, e.g. renal and/or liver failure.