Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery

Launched by MOUNT SINAI HOSPITAL, CANADA · Sep 14, 2005

Keywords

ClinConnect Summary

Preterm labour involves multiple causes - one of the most significant factors being a prior history of preterm birth. Infection is another major cause of preterm labour (PTL) and is estimated to cause up to 30% of PTL. Bacterial Vaginosis (BV) is an alteration in the endogenous vaginal microflora preceded by a decreased presence of Lactobacilli species and increased growth of gardnerella and other pathogens. BV is a strong risk factor for PTL, and is associated with a 40% increased risk in some populations. Initial studies suggested that the treatment of BV with antibiotics could decrease t...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • pregnant women with previous incidence of preterm labour
• • otherwise healthy
• • over 18 years of age
• • able to provide informed consent
• • less than or equal to 16 weeks gestation
• • singleton pregnancy
• • normal uterine cavity
• Exclusion Criteria:
• • significant medical complications (preeclampsia, thrombophilia, hypertension)
• • multiple pregnancy
• • less than 18 years of age
• • patients receiving antibiotics or other antimicrobial therapies at time of recruitment
• • fetal complications such as intrauterine growth restriction or other abnormalities
• • diabetes
• • documented need for cervical cerclage
• • patient enrolled in other clinical trials