Urinary Tract Infection Study With the Antibiotic Levofloxacin Given at a Higher Dose Over a Shorter Period of Time

Launched by UNIVERSITY OF MANITOBA · Oct 27, 2005

Keywords

ClinConnect Summary

This study will be a pilot study of the efficacy of 750 mg of levofloxacin once daily for 5 days in the treatment of complicated urinary tract infection.

The specific objectives include:

1. To describe clinical and microbiological outcome at short and long term follow-up with 5 days levofloxacin in subjects with acute symptomatic complicated urinary infection, both with and without indwelling catheters.
2. To determine the tolerability of levofloxacin 750-mg once daily in patients with complicated urinary infection.
3. To describe some characteristics of the resolution of the inflammatory...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Acute symptoms of urinary infection of less than 7 days duration and an underlying structural or functional abnormality of the genitourinary tract.
• • 2. Pre-therapy urine culture \> 105 cfu/ml (\> 108 cfu/L) of at least one urinary pathogen.
• • 3. Age 18-80 years, male or female.
• Exclusion Criteria:
• • 1. Prior allergic reaction to any fluoroquinolone antimicrobial.
• • 2. Known infection with a fluoroquinolone - resistant organism.
• • 3. Requiring parenteral therapy because of severity of illness or unable to take oral medications.
• • 4. Women who are pregnant or breastfeeding.
• • 5. Requiring additional antimicrobial therapy for infections elsewhere.