Esophageal Cancer Risk Registry

Launched by UNIVERSITY OF PITTSBURGH · Nov 28, 2005

Keywords

ClinConnect Summary

The Esophageal Cancer Risk Registry trial is designed to help researchers find signs in blood and tissue that could show a person's risk of developing esophageal cancer. By studying patients with certain esophageal disorders, like gastroesophageal reflux disease (GERD), Barrett's metaplasia, or hiatal hernia, the study aims to discover genetic and lifestyle factors that might lead to cancer. Understanding these factors could help doctors catch the disease earlier and improve chances for successful treatment.

To participate in the trial, individuals should be between the ages of 65 and 74 and have a known or suspected esophageal condition, such as Barrett's metaplasia or achalasia. Participants will provide medical history and samples of blood and tissue for testing. It's important to note that people with specific blood conditions may not be eligible for additional biopsies needed for this study. Overall, this research could make a big difference in how we detect and prevent esophageal cancer in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Known or suspected esophageal or gastroesophageal junction malignancy
• • Known Barrett's metaplasia
• • Clinical management of symptomatic gastroesophageal reflux disease (GERD)
• • Achalasia
• • Hiatal hernia
• Exclusion Criteria:
• • Elevated pre-operative bloodwork will not have the additional biopsies taken.
• • Platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and/or International Normalized Ratio (INR) of 1.8 or above will not have the additional biopsies taken.